Systemic Immunoregulatory Consequences of Gut Commensal Translocation.
Systemic Immunoregulatory Consequences of Gut Commensal Translocation.
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DOI：
10.1016/j.it.2020.12.005
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发表时间：
2021-02
影响因子：
16.8
通讯作者：
Meisel, Marlies
中科院分区：
文献类型：
--
作者：
McPherson, Alex C.;Pandey, Surya P.;Bender, Mackenzie J.;Meisel, Marlies
在体内平衡和某些复杂的多因素疾病(如癌症和自身免疫疾病)中，系统免疫的一个主要决定因素是肠道微生物区系。这些共生体可以通过代谢产物、微生物细胞壁成分和活微生物的移位来形成全身免疫反应。在过去的几年中，细菌易位在非胃肠道疾病的免疫调节过程中发挥着关键的、潜在的因果作用。此外，最近关于动态平衡期间肠道远端组织中存在复杂的微生物群落和活细菌的观察结果挑战了当前的范式，即健康的哺乳动物在非粘膜部位完全无菌。这篇综述讨论了我们目前对肠道微生物区系如何在非传染性肠外疾病和动态平衡期间协调系统免疫的理解，重点是活细菌到肠道远端部位的移位。
One major determinant of systemic immunity during homeostasis and in certain complex multifactorial diseases (e.g. cancer and autoimmune conditions), is the gut microbiota. These commensals can shape systemic immune responses via translocation of metabolites, microbial cell wall components, and viable microbes. In the last few years, bacterial translocation has revealed itself as playing a key, and potentially causal role in mediating immunomodulatory processes in nongastrointestinal diseases. Moreover, recent observations regarding the presence of complex microbial communities and viable bacteria within gut-distal tissues during homeostasis challenge the current paradigm that healthy mammals are entirely sterile at nonmucosal sites. This review discusses our current understanding of how the gut microbiota orchestrates systemic immunity during non-infectious extraintestinal diseases and homeostasis, focusing on the translocation of viable bacteria to gut-distal sites.
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影响因子：
32.4
作者：
Fung TC;Bessman NJ;Hepworth MR;Kumar N;Shibata N;Kobuley D;Wang K;Ziegler CGK;Goc J;Shima T;Umesaki Y;Sartor RB;Sullivan KV;Lawley TD;Kunisawa J;Kiyono H;Sonnenberg GF
通讯作者：
Sonnenberg GF
影响因子：
2.9
作者：
Brenner DA;Paik YH;Schnabl B
通讯作者：
Schnabl B
影响因子：
32.4
作者：
Bunker JJ;Flynn TM;Koval JC;Shaw DG;Meisel M;McDonald BD;Ishizuka IE;Dent AL;Wilson PC;Jabri B;Antonopoulos DA;Bendelac A
通讯作者：
Bendelac A
影响因子：
32.4
作者：
Dorrestein PC;Mazmanian SK;Knight R
通讯作者：
Knight R
影响因子：
25.7
作者：
Fouts, Derrick E.;Torralba, Manolito;Nelson, Karen E.;Brenner, David A.;Schnabl, Bernd
通讯作者：
Schnabl, Bernd