CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration.
CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration.
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DOI：
10.1002/stem.759
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发表时间：
2011-12
期刊：
影响因子：
5.2
通讯作者：
Rossi, Fabio M. V.
中科院分区：
文献类型：
--
作者：
Alfaro, Leslie Ann So;Dick, Sarah A.;Siegel, Ashley L.;Anonuevo, Adam S.;McNagny, Kelly M.;Megeney, Lynn A.;Cornelison, D. D. W.;Rossi, Fabio M. V.
Expression of the cell surface sialomucin CD34 is common to many adult stem cell types, including muscle satellite cells. However, no clear stem cell or regeneration-related phenotype has ever been reported in mice lacking CD34, and its function on these cells remains poorly understood. Here, we assess the functional role of CD34 on satellite cell-mediated muscle regeneration. We show that Cd34−/− mice, which have no obvious developmental phenotype, display a defect in muscle regeneration when challenged with either acute or chronic muscle injury. This regenerative defect is caused by impaired entry into proliferation and delayed myogenic progression. Consistent with the reported anti-adhesive function of CD34, knock out satellite cells also show decreased motility along their host myofiber. Altogether, our results identify a role for CD34 in the poorly understood early steps of satellite cell activation, and provide the first evidence that beyond being a stem cell marker, CD34 may play an important function in modulating stem cell activity.
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DOI：
10.1084/jem.194.1.13
发表时间：
2001-07-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Doyonnas R;Kershaw DB;Duhme C;Merkens H;Chelliah S;Graf T;McNagny KM
通讯作者：
McNagny KM
影响因子：
11.8
作者：
Griffin CA;Kafadar KA;Pavlath GK
通讯作者：
Pavlath GK
DOI：
10.1007/978-1-60761-063-2_11
发表时间：
2010-01-01
期刊：
PROTOCOLS FOR ADULT STEM CELLS
影响因子：
--
作者：
Conboy, Michael J.;Cerletti, Massimiliano;Conboy, Irina M.
通讯作者：
Conboy, Irina M.
影响因子：
3.7
作者：
Ieronimakis, Nicholas;Balasundaram, Gayathri;Reyes, Morayma
通讯作者：
Reyes, Morayma
影响因子：
32.4
作者：
Drew, E;Merzaban, JS;McNagny, KM
通讯作者：
McNagny, KM