Modified natural nanoparticles as contrast agents for medical imaging.
Modified natural nanoparticles as contrast agents for medical imaging.
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DOI：
10.1016/j.addr.2009.11.005
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发表时间：
2010-03-08
影响因子：
16.1
通讯作者：
Fayad, Zahi A.
中科院分区：
文献类型：
--
作者：
Cormode, David P.;Jarzyna, Peter A.;Mulder, Willem J. M.;Fayad, Zahi A.
The development of novel and effective contrast agents is one of the drivers of the ongoing improvement in medical imaging. Many of the new agents reported are nanoparticle-based. There are a variety of natural nanoparticles known, e.g. lipoproteins, viruses or ferritin. Natural nanoparticles have advantages as delivery platforms such as biodegradability. In addition, our understanding of natural nanoparticles is quite advanced, allowing their adaptation as contrast agents. They can be labeled with small molecules or ions such as Gd3+ to act as contrast agents for magnetic resonance imaging, 18F to act as positron emission tomography contrast agents or fluorophores to act as contrast agents for fluorescence techniques. Additionally, inorganic nanoparticles such as iron oxide, gold nanoparticles or quantum dots can be incorporated to add further contrast functionality. Furthermore, these natural nanoparticle contrast agents can be rerouted from their natural targets via the attachment of targeting molecules. In this review, we discuss the various modified natural nanoparticles that have been exploited as contrast agents.
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DOI：
10.1021/jp8108286
发表时间：
2009-05-07
期刊：
The journal of physical chemistry. B
影响因子：
--
作者：
Briley-Saebo KC;Geninatti-Crich S;Cormode DP;Barazza A;Mulder WJ;Chen W;Giovenzana GB;Fisher EA;Aime S;Fayad ZA
通讯作者：
Fayad ZA
影响因子：
3.4
作者：
Bennett, Kevin M.;Shapiro, Erik M.;Koretsky, Alan P.
通讯作者：
Koretsky, Alan P.
影响因子：
10.8
作者：
Chen, C;Daniel, MC;Dragnea, B
通讯作者：
Dragnea, B
影响因子：
3.5
作者：
Carlisle, Robert C.;Benjamin, Reuben;Fisher, Kerry D.
通讯作者：
Fisher, Kerry D.
影响因子：
10.8
作者：
Cormode DP;Skajaa T;van Schooneveld MM;Koole R;Jarzyna P;Lobatto ME;Calcagno C;Barazza A;Gordon RE;Zanzonico P;Fisher EA;Fayad ZA;Mulder WJ
通讯作者：
Mulder WJ