Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform.

Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform.
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DOI:
10.1021/nl801958b
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发表时间:
2008-11
期刊:
影响因子:
10.8
通讯作者:
Mulder WJ
Mulder WJ
中科院分区:
材料科学1区
文献类型:
--
作者:
Cormode DP;Skajaa T;van Schooneveld MM;Koole R;Jarzyna P;Lobatto ME;Calcagno C;Barazza A;Gordon RE;Zanzonico P;Fisher EA;Fayad ZA;Mulder WJ

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高密度脂蛋白(HDL)是一种重要的天然纳米颗粒,可以被修饰用于生物医学成像目的。在这里,我们开发了一种新的技术,以创建独特的多模态HDL模拟纳米颗粒,包括金,氧化铁或量子点纳米晶体的计算机断层扫描,磁共振和荧光成像,分别。通过在颗粒的冠中包括额外的标记,它们被制成多功能的。这些纳米颗粒的表征以及它们的体外和体内行为表明,它们与天然HDL非常相似。
High density lipoprotein (HDL), is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique to create unique multimodality HDL mimicking nanoparticles by inclusion of gold, iron oxide or quantum dot nanocrystals for computed tomography, magnetic resonance and fluorescence imaging, respectively. By including additional labels in the corona of the particles, they were made multi-functional. The characterization of these nanoparticles, as well as their in vitro and in vivo behavior revealed that they closely mimic native HDL.
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