Requirement for engrailed and invected genes reveals novel regulatory interactions between engrailed/invected, patched, gooseberry and wingless during Drosophila neurogenesis.
Requirement for engrailed and invected genes reveals novel regulatory interactions between engrailed/invected, patched, gooseberry and wingless during Drosophila neurogenesis.
复制标题
对 engrailed 和 invected 基因的需求揭示了果蝇神经发生过程中 engrailed/invected、patched、gooseberry 和 wingless 之间新的调控相互作用。
作者：
K. Bhat;P. Schedl
During neurogenesis, the transmembrane protein Patched (Ptc) promotes a wingless (wg)-mediated specification of a neuronal precursor cell, NB4-2, by repressing gooseberry (gsb). In this study, novel interactions of these genes with engrailed (en) and invected (inv) during neurogenesis have been uncovered. While in row 4 cells Ptc represses gsb and wg, in row 5 cells en/inv relieve Ptc repression of gsb by a non-autonomous mechanism that does not involve hedgehog (hh). This differential regulation of gsb leads to the specification of NB5-3 and NB4-2 identities to two distinct neuroblasts. The uncoupling of the ptc-gsb regulatory circuit also enables gsb to promote Wg expression in row 5 cells. Our results suggest that the en/inv-->ptc-->gsb-->wg pathway uncovered here and the hh-->wg are distinct pathways that function to maintain wild-type level of Wg. Our results also indicate that Hh is not the only ligand for Ptc and similarly Ptc is not the only receptor for Hh.
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影响因子：
10.5
作者：
N. Patel;B. Schafer;C. Goodman;R. Holmgren
通讯作者：
N. Patel;B. Schafer;C. Goodman;R. Holmgren
修补过表达会导致果蝇胚胎中无翅表达的丧失。
影响因子：
2.7
作者：
Schuske,K;Hooper,JE;Scott,MP
通讯作者：
Scott,MP
节段极性基因相互作用调节果蝇胚胎的表皮图案。
DOI：
10.1242/dev.119.2.501
发表时间：
1993
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Bejsovec,A;Wieschaus,E
通讯作者：
Wieschaus,E
果蝇醋栗远端或近端基因的异位表达会导致表皮和中枢神经系统细胞命运的改变。
DOI：
10.1242/dev.120.5.1151
发表时间：
1994
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Zhang,Y;Ungar,A;Fresquez,C;Holmgren,R
通讯作者：
Holmgren,R