Childhood adversity as a risk for cancer: findings from the 1958 British birth cohort study.
Childhood adversity as a risk for cancer: findings from the 1958 British birth cohort study.
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DOI：
10.1186/1471-2458-13-767
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发表时间：
2013-08-19
影响因子：
4.5
通讯作者：
Delpierre C
中科院分区：
文献类型：
--
作者：
Kelly-Irving M;Lepage B;Dedieu D;Lacey R;Cable N;Bartley M;Blane D;Grosclaude P;Lang T;Delpierre C
分析不良童年经历 (ACE) 是否与癌症风险增加相关。国家儿童发展研究 (NCDS) 是一项前瞻性出生队列研究，收集了 50 多年的数据。 NCDS 包括 1958 年英国一周内的所有活产婴儿 (n = 18558)。自我报告的癌症发病率基于 444 名参与者报告曾患过癌症，5694 名参与者报告从未患过癌症。 ACE 使用以下报告进行衡量：1) 受照顾的儿童，2) 身体忽视，3) 儿童或家庭与监狱部门的接触，4) 父母因离婚、死亡或其他原因分居，5) 家庭精神疾病经历，以及 6) 家庭药物滥用经历。生成的变量具有三类：无 ACE/1 个 ACE/2 + ACE，用于测试与癌症的关系。有关社会经济特征、怀孕和出生的信息被提取为潜在的混杂因素。模型中添加了有关成人健康行为、社会经济环境、心理状态和首次怀孕年龄的信息。使用多重插补数据运行多变量模型来解释队列中缺失的数据。调整成人因素和早期生活混杂因素后，具有 2+ ACE 的女性与没有 ACE 的女性相比，在 50 岁之前患癌症的几率增加了一倍（OR：2.1，95% CI：1.42-3.21，p<0.001）。这些发现表明，癌症风险可能会受到生命早期接触的压力条件和事件的影响。这对于加深我们对癌症病因学的理解，从而调整科学研究方向和制定适当的预防政策具有潜在的重要意义。
To analyse whether Adverse Childhood Experiences (ACE) are associated with an increased risk of cancer. The National child development study (NCDS) is a prospective birth cohort study with data collected over 50 years. The NCDS included all live births during one week in 1958 (n = 18558) in Great Britain. Self-reported cancer incidence was based on 444 participants reporting having had cancer at some point and 5694 reporting never having cancer. ACE was measured using reports of: 1) child in care, 2) physical neglect, 3) child’s or family’s contact with the prison service, 4) parental separation due to divorce, death or other, 5) family experience of mental illness & 6) family experience of substance abuse. The resulting variable had three categories, no ACEs/ one ACE/ 2 + ACEs and was used to test for a relationship with cancer. Information on socioeconomic characteristics, pregnancy and birth were extracted as potential confounders. Information on adult health behaviours, socioeconomic environment, psychological state and age at first pregnancy were added to the models. Multivariate models were run using multiply-imputed data to account for missing data in the cohort. The odds of having a cancer before 50 y among women increased twofold for those who had 2+ ACEs versus those with no ACEs, after adjusting for adult factors and early life confounders (OR: 2.1, 95% CI: 1.42-3.21, p < 0.001). These findings suggest that cancer risk may be influenced by exposure to stressful conditions and events early on in life. This is potentially important in furthering our understanding of cancer aetiology, and consequently in redirecting scientific research and developing appropriate prevention policies.
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影响因子：
5
作者：
Desai, MM;Bruce, ML;Druss, BG
通讯作者：
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影响因子：
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作者：
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作者：
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作者：
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作者：
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通讯作者：
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