The Signaling Pathway of TNF Receptors: Linking Animal Models of Renal Disease to Human CKD.
The Signaling Pathway of TNF Receptors: Linking Animal Models of Renal Disease to Human CKD.
复制标题
肿瘤坏死因子受体的信号通路：将肾脏疾病动物模型与人类慢性肾脏病联系起来。
DOI：
10.3390/ijms23063284
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发表时间：
2022-03-18
影响因子：
5.6
通讯作者：
Belo L
中科院分区：
文献类型：
--
作者：
Lousa I;Reis F;Santos-Silva A;Belo L
慢性肾脏疾病（CKD）已被认为是一个全球性的公共卫生问题。尽管目前医学取得了进步，但ckd相关的发病率和死亡率仍然高得令人无法接受。一些研究强调了炎症和炎症介质对CKD发生和/或进展的贡献，例如肿瘤坏死因子（TNF）相关的生物标志物。由TNF-α通过TNF受体1 （TNFR1）和2 （TNFR2）驱动的炎症通路涉及CKD发病机制中的重要介质。tnfr的循环水平与肾功能和损伤的其他生物标志物的变化相关，并且在一些患者队列中被描述为疾病进展、心血管发病率和死亡率的预测因子。实验研究描述了TNFR激活诱导的可能的下游信号通路和由此产生的生物反应。本综述将重点介绍TNFR1和TNFR2的现有数据，并说明它们在肾脏疾病病理生理中的作用，它们的细胞和分子作用，以及它们作为CKD生物标志物的潜力。新出现的证据表明TNF受体可以作为肾脏损伤的生物标志物和疾病的介质。此外，有研究表明，这些生物标志物可以显著提高CKD临床预后模型的区分。
Chronic kidney disease (CKD) has been recognized as a global public health problem. Despite the current advances in medicine, CKD-associated morbidity and mortality remain unacceptably high. Several studies have highlighted the contribution of inflammation and inflammatory mediators to the development and/or progression of CKD, such as tumor necrosis factor (TNF)-related biomarkers. The inflammation pathway driven by TNF-α, through TNF receptors 1 (TNFR1) and 2 (TNFR2), involves important mediators in the pathogenesis of CKD. Circulating levels of TNFRs were associated with changes in other biomarkers of kidney function and injury, and were described as predictors of disease progression, cardiovascular morbidity, and mortality in several cohorts of patients. Experimental studies describe the possible downstream signaling pathways induced upon TNFR activation and the resulting biological responses. This review will focus on the available data on TNFR1 and TNFR2, and illustrates their contributions to the pathophysiology of kidney diseases, their cellular and molecular roles, as well as their potential as CKD biomarkers. The emerging evidence shows that TNF receptors could act as biomarkers of renal damage and as mediators of the disease. Furthermore, it has been suggested that these biomarkers could significantly improve the discrimination of clinical CKD prognostic models.
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影响因子：
16
作者：
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通讯作者：
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