Hepatocyte-stellate cell synapse in alcohol-induced steatosis: another role for endocannabinoids.

Hepatocyte-stellate cell synapse in alcohol-induced steatosis: another role for endocannabinoids.
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DOI:
10.1038/s41575-019-0233-8
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发表时间:
2020-01
期刊:
Nature reviews. Gastroenterology & hepatology
影响因子:
--
通讯作者:
Bataller R
Bataller R
中科院分区:
其他
文献类型:
--
作者:
Argemi J;Bataller R

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A new study demonstrates a novel role for an endocannabinoid in promoting hepatocyte steatosis. The study describes a mode of bidirectional communication between the alcohol-injured hepatocyte and the glutamate-activated hepatic stellate cell. This intercellular communication represents a novel targetable pathogenic mechanism that could lead to new strategies to prevent fatty liver disease progression to cirrhosis.
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