Coactivation of thalamic and cortical pathways induces input timing-dependent plasticity in amygdala.
Coactivation of thalamic and cortical pathways induces input timing-dependent plasticity in amygdala.
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丘脑和皮质途径的共激活可在杏仁核中诱导输入时间依赖性可塑性。
DOI：
10.1038/nn.2993
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发表时间：
2011-12-11
影响因子：
25
通讯作者：
中科院分区：
文献类型：
--
作者：
Long-term synaptic enhancements in cortical and thalamic auditory inputs to the lateral nucleus of the amygdala (LAn) mediate encoding of conditioned fear memory. It remained unknown, however, whether the convergent auditory conditioned stimulus (CSa) pathways may interact with each other producing changes in their synaptic function. Here we show that continuous paired stimulation of thalamic and cortical auditory inputs to the LAn with the interstimulus delay approximately mimicking a temporal pattern of their activation in behaving animals during auditory fear conditioning results in persistent potentiation of synaptic transmission in cortico-amygdala pathway in rat brain slices. This novel form of input timing-dependent plasticity (ITDP) in cortical input depends on InsP3-sensitive Ca2+ release from the internal stores and postsynaptic Ca2+ influx through calcium-permeable kainate receptors during its induction. ITDP in the auditory projections to the LAn, determined by characteristics of presynaptic activity patterns, may contribute to the encoding of the complex CSa.
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影响因子：
25
作者：
Li, H;Chen, AQ;Rogawski, MA
通讯作者：
Rogawski, MA
影响因子：
3.4
作者：
Doyère, V;Schafe, GE;LeDoux, JE
通讯作者：
LeDoux, JE
影响因子：
25
作者：
Bissière, S;Humeau, Y;Lüthi, A
通讯作者：
Lüthi, A
影响因子：
2.9
作者：
Koike, M;Iino, M;Ozawa, S
通讯作者：
Ozawa, S
影响因子：
3.5
作者：
Johnson LR;Hou M;Ponce-Alvarez A;Gribelyuk LM;Alphs HH;Albert L;Brown BL;Ledoux JE;Doyère V
通讯作者：
Doyère V