Cutting edge: Hierarchy of maturity of murine memory B cell subsets.
Cutting edge: Hierarchy of maturity of murine memory B cell subsets.
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DOI：
10.4049/jimmunol.1002163
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发表时间：
2010-12-15
期刊：
影响因子：
--
通讯作者：
Shlomchik MJ
中科院分区：
文献类型：
--
作者：
Tomayko MM;Steinel NC;Anderson SM;Shlomchik MJ
小鼠记忆B细胞标记物的缺乏一直是记忆研究的重要障碍。最常用的标记物是IgG，它既不敏感也不特异，因为激活的非记忆细胞可以是IgG+，而记忆细胞可以是IgM+。在这篇文章中，我们表明，PD-L2（CD 273），CD 80，和CD 73定义至少五个表型子集的小鼠记忆B细胞。这些亚群由携带单个BCR的幼稚细胞产生，以响应单个T依赖性Ag。这种多样性是独立的类开关，因为IgG 1和IgM轴承记忆细胞内发现每个隔室。由PD-L2，CD 80和CD 73定义的记忆子集在生物学上彼此不同，因为它们在个体发育和选择方面不同。总而言之，这些差异表明存在一系列记忆B细胞，并且从更幼稚的性质到更记忆的性质进行渐进获得。
The paucity of murine memory B cell markers has been a significant impediment to the study of memory. The most commonly used marker is IgG, which is neither sensitive nor specific, because activated nonmemory cells can be IgG+, and memory cells can be IgM+. In this article, we show that, together, PD-L2 (CD273), CD80, and CD73 define at least five phenotypic subsets of murine memory B cells. These subsets are generated from naive cells bearing a single BCR in response to a single T-dependent Ag. This diversity is independent of class switch, because IgG1- and IgM-bearing memory cells are found within each compartment. Memory subsets defined by PD-L2, CD80, and CD73 are biologically distinct from one another, because they differ in ontogeny and selection. Together, these distinctions suggest that there is a spectrum of memory B cells and progressive acquisition from more naive-like to more memory-like properties.
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影响因子：
4.4
作者：
SHLOMCHIK, MJ;ZHARHARY, D;WEIGERT, MG
通讯作者：
WEIGERT, MG
影响因子：
15.3
作者：
McHeyzer-Williams, M G;McLean, M J;Lalor, P A;Nossal, G J
通讯作者：
Nossal, G J
DOI：
10.1084/jem.20062571
发表时间：
2007-09-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Anderson SM;Tomayko MM;Ahuja A;Haberman AM;Shlomchik MJ
通讯作者：
Shlomchik MJ
影响因子：
100.3
作者：
Lefrancois, Leo;Marzo, Amanda
通讯作者：
Marzo, Amanda
影响因子：
30.5
作者：
Dogan, Ismail;Bertocci, Barbara;Weill, Jean-Claude
通讯作者：
Weill, Jean-Claude