Botulinum Toxin Therapy: A Series of Clinical Studies on Patients with Spasmodic Dysphonia in Japan.
Botulinum Toxin Therapy: A Series of Clinical Studies on Patients with Spasmodic Dysphonia in Japan.
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DOI：
10.3390/toxins13120840
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发表时间：
2021-11-25
期刊：
影响因子：
4.2
通讯作者：
Nishizawa N
中科院分区：
文献类型：
--
作者：
Hyodo M;Asano K;Nagao A;Hirose K;Nakahira M;Yanagida S;Nishizawa N
痉挛性发声障碍是一种罕见的发声障碍，由喉肌不自主和间歇性痉挛引起。诊断和治疗一直存在争议。因此，最近在日本进行了一系列临床研究。一项全国性流行病学调查显示，内收肌SD占主导地位（占所有病例的90-95%; 3.5-7.0/100 000），主要发生在20多岁和30多岁的年轻女性中。为了便于早期诊断，我们创建了SD的诊断标准和严重程度分级系统。诊断标准包括主要症状和伴随症状、发声时的临床表现、治疗反应和鉴别诊断。使用主观和客观评估的组合来确定严重程度等级。肉毒杆菌毒素（BT）注射是治疗的选择;然而，几乎没有高质量的临床研究，BT已被用于标签外。我们进行了一项安慰剂对照、随机、双盲的BT治疗临床试验;这是有效和安全的。BT治疗现在由日本医疗保险计划资助。迄今为止的研究促进了早期诊断和适当的治疗;他们培养了患者对SD的认识。
Spasmodic dysphonia (SD) is a rare voice disorder caused by involuntary and intermittent spasms of the laryngeal muscles. Both diagnosis and treatment have been controversial. Therefore, a series of clinical studies has recently been conducted in Japan. A nationwide epidemiological survey revealed that adductor SD predominated (90–95% of all cases; 3.5–7.0/100,000), principally among young women in their 20s and 30s. To facilitate early diagnosis, we created diagnostic criteria for SD and a severity grading system. The diagnostic criteria include the principal and accompanying symptoms, clinical findings during phonation, the treatment response, and the differential diagnoses. The severity grade is determined using a combination of subjective and objective assessments. Botulinum toxin (BT) injection is the treatment of choice; however, there have been few high-quality clinical studies and BT has been used off-label. We conducted a placebo-controlled, randomized, double-blinded clinical trial of BT therapy; this was effective and safe. BT treatment is now funded by the Japanese medical insurance scheme. Studies thus far have facilitated early diagnosis and appropriate therapy; they have fostered patient awareness of SD.
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DOI：
10.1186/s40734-017-0066-y
发表时间：
2017
期刊：
Journal of clinical movement disorders
影响因子：
--
作者：
Stewart CF;Sinclair CF;Kling IF;Diamond BE;Blitzer A
通讯作者：
Blitzer A
DOI：
10.1016/j.jvoice.2013.10.022
发表时间：
2015-09
期刊：
Journal of voice : official journal of the Voice Foundation
影响因子：
--
作者：
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通讯作者：
Johns MM
影响因子：
8.6
作者：
Asgeirsson, H;Jakobsson, F;Sveinbjornsdottir, S
通讯作者：
Sveinbjornsdottir, S
影响因子：
1.4
作者：
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影响因子：
2.2
作者：
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通讯作者：
Woodson, Gayle E.