Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements.
Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements.
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DOI：
10.1007/s00018-010-0383-x
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发表时间：
2010-09
影响因子：
8
通讯作者：
Khabar, Khalid S. A.
中科院分区：
文献类型：
--
作者：
Khabar, Khalid S. A.
大量编码富au mrna的基因，包括细胞因子、生长因子、转录因子和某些受体，都与慢性炎症和癌症有关。这些基因的过度表达受到畸变或几个信号通路延长激活的影响。富au元素（ARE）是3'UTR中重要的顺式作用短序列，介导一系列rna结合蛋白的识别，影响mRNA的稳定性和翻译。本文综述了炎症和癌症之间常见的细胞和分子机制，以及介导的转录后控制。第一部分研究are基因在炎症和癌症中的作用以及富au元素的序列特征。第二部分阐述了炎症和癌症中调节are介导通路的常见信号通路，以及它们的解除调控如何影响are基因调控和疾病结果。
A considerable number of genes that code for AU-rich mRNAs including cytokines, growth factors, transcriptional factors, and certain receptors are involved in both chronic inflammation and cancer. Overexpression of these genes is affected by aberrations or by prolonged activation of several signaling pathways. AU-rich elements (ARE) are important cis-acting short sequences in the 3′UTR that mediate recognition of an array of RNA-binding proteins and affect mRNA stability and translation. This review addresses the cellular and molecular mechanisms that are common between inflammation and cancer and that also govern ARE-mediated post-transcriptional control. The first part examines the role of the ARE-genes in inflammation and cancer and sequence characteristics of AU-rich elements. The second part addresses the common signaling pathways in inflammation and cancer that regulate the ARE-mediated pathways and how their deregulations affect ARE-gene regulation and disease outcome.
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影响因子：
14.9
作者：
Bakheet T;Williams BR;Khabar KS
通讯作者：
Khabar KS
影响因子：
14.2
作者：
Casolaro, Vincenzo;Fang, Xi;Stellato, Cristiana
通讯作者：
Stellato, Cristiana
影响因子：
11.2
作者：
Brennan SE;Kuwano Y;Alkharouf N;Blackshear PJ;Gorospe M;Wilson GM
通讯作者：
Wilson GM
影响因子：
14.9
作者：
Barreau C;Paillard L;Osborne HB
通讯作者：
Osborne HB
DOI：
10.1073/pnas.96.6.3047
发表时间：
1999-03-16
影响因子：
11.1
作者：
Chesney, J;Mitchell, R;Bucala, R
通讯作者：
Bucala, R