Effects of Withdrawal from Chronic Intermittent Ethanol Exposure on Sleep Characteristics of Female and Male Mice.
Effects of Withdrawal from Chronic Intermittent Ethanol Exposure on Sleep Characteristics of Female and Male Mice.
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DOI：
10.1111/acer.13584
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Roberts AJ
中科院分区：
文献类型：
--
作者：
Huitron-Resendiz S;Nadav T;Krause S;Cates-Gatto C;Polis I;Roberts AJ
睡眠障碍是酒精使用障碍的一个重要后果。尽管记录在案的酒精相关行为和戒断症状的性别差异，但研究与酒精依赖相关的睡眠模式的性别差异的临床前研究很少。本研究旨在探讨慢性间歇性乙醇(Etoh)对雌性和雄性小鼠睡眠特征的影响。雌性和雄性C57BL6/J小鼠接受乙醇/水两瓶选择(2BC)，每天2小时，连续3周，然后暴露于乙醇蒸气(蒸汽-2BC)或空气(对照-2BC)，共5个周期，共4天。另外一组人从未经历过Etoh(幼稚)。小鼠被植入脑电电极，并在戒断第四天的24小时内记录警觉状态。计算觉醒(W)、慢波睡眠(SWS)和快速眼动(REM)睡眠时间，并用快速傅立叶变换进行频谱分析。总体而言，蒸气2BC小鼠在停药四天后SWS数量减少，慢波功率密度下降，这表明Etoh依赖小鼠的睡眠时间和质量都受到了破坏。这与男性持续时间的缩短和SWS发作次数的增加以及女性睡眠潜伏期的延长有关。我们的结果揭示了乙醇依赖小鼠的睡眠调节的总体缺陷，无论性别。雌性小鼠似乎在睡眠触发方面受到的影响更大，而雄性小鼠似乎对睡眠维持过程中的干扰更敏感。
Sleep disruptions are an important consequence of alcohol use disorders. There is a dearth of preclinical studies examining sex differences in sleep patterns associated with ethanol dependence despite documented sex differences in alcohol related behaviors and withdrawal symptoms. The purpose of this study was to investigate the effects of chronic intermittent ethanol (EtOH) on sleep characteristics in female and male mice. Female and male C57BL6/J mice had access to EtOH/water two bottle choice (2BC) 2hr/day for 3 weeks followed by exposure to EtOH vapor (vapor-2BC) or air (control-2BC) for 5 cycles of 4 days. An additional group never experienced EtOH (naïve). Mice were implanted with EEG electrodes and vigilance states were recorded across 24hr on the fourth day of withdrawal. The amounts of wakefulness (W), slow-wave sleep (SWS), and rapid eye movement (REM) sleep were calculated and spectral analysis was performed by fast Fourier transformation. Overall, vapor-2BC mice showed a decrease in the amount of SWS four days into withdrawal as well as a decrease in the power density of slow waves, indicating disruptions in both the amount and quality of sleep in EtOH dependent mice. This was associated with a decrease in duration and an increase in number of SWS episodes in males and an increase in latency to sleep in females. Our results revealed overall deficits in sleep regulation in EtOH dependent mice of both sexes. Female mice appeared to be more affected with regard to the triggering of sleep, while male mice appeared more sensitive to disruptions in the maintenance of sleep.
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影响因子：
3.4
作者：
Bourgin, Patrice;Fabre, Veronique;de Lecea, Luis
通讯作者：
de Lecea, Luis
DOI：
10.1111/j.1530-0277.2010.01417.x
发表时间：
2011-05
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Arnedt JT;Rohsenow DJ;Almeida AB;Hunt SK;Gokhale M;Gottlieb DJ;Howland J
通讯作者：
Howland J
影响因子：
3.5
作者：
Finn DA;Beckley EH;Kaufman KR;Ford MM
通讯作者：
Ford MM
影响因子：
2.3
作者：
Brower, Kirk J.
通讯作者：
Brower, Kirk J.
影响因子：
3.3
作者：
Bray JG;Roberts AJ;Gruol DL
通讯作者：
Gruol DL