Sleep following alcohol intoxication in healthy, young adults: effects of sex and family history of alcoholism.
Sleep following alcohol intoxication in healthy, young adults: effects of sex and family history of alcoholism.
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DOI：
10.1111/j.1530-0277.2010.01417.x
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Howland J
中科院分区：
文献类型：
--
作者：
Arnedt JT;Rohsenow DJ;Almeida AB;Hunt SK;Gokhale M;Gottlieb DJ;Howland J
这项研究评估了性别和酗酒家族史作为健康年轻人酒精中毒后嗜睡/睡眠质量和多导睡眠图主观评分的调节因素。招募了93名健康成年人（平均年龄24.4 ± 2.7岁，59名女性，29名有阳性酒精中毒家族史（FH+）的受试者）。在筛选多导睡眠图后，受试者在2030至2200小时之间饮酒（性别/体重调整剂量）至中毒（男性和女性的呼气酒精浓度峰值[BrAC]为0.11 ± 0.01 g %）或匹配安慰剂。睡眠监测与多导睡眠图之间的2300和0700小时。参与者在睡前和醒来时完成了斯坦福大学嗜睡量表和卡罗林斯卡嗜睡量表，并进行了有效的睡眠后问卷调查。饮酒后，女性的总睡眠时间、睡眠效率、夜间觉醒和入睡后觉醒受到的干扰比男性多，但家族史状态没有差异。与安慰剂相比，酒精减少了睡眠开始潜伏期，睡眠效率和REM睡眠，同时增加了整晚的觉醒和慢波睡眠。酒精通常也会在前半夜增加睡眠巩固，但在后半夜减少。饮酒后的嗜睡程度更高，尤其是女性在睡前。早晨睡眠质量评分低于酒精比安慰剂。酒精中毒增加主观嗜睡和干扰睡眠客观上在健康女性比男性，没有明显的差异，酒精中毒状态的家族史。评估酒精对睡眠影响的调节因子可能有助于深入了解睡眠在饮酒问题中的作用。
This study evaluated sex and family history of alcoholism as moderators of subjective ratings of sleepiness/sleep quality and polysomnography following alcohol intoxication in healthy, young adults. Ninety-three healthy adults (mean age 24.4 ± 2.7 years, 59 women, 29 subjects with a positive family history of alcoholism (FH+)) were recruited. Following screening polysomnography, participants consumed alcohol (sex/weight adjusted dosing) to intoxication (peak breath alcohol concentration [BrAC] of 0.11 ± 0.01 g% for men and women) or matching placebo between 2030 and 2200 hours. Sleep was monitored with polysomnography between 2300 and 0700 hours. Participants completed the Stanford Sleepiness Scale and Karolinska Sleepiness Scale at bedtime and on awakening and a validated post-sleep questionnaire. Following alcohol, total sleep time, sleep efficiency, nighttime awakenings, and wake after sleep onset were more disrupted in women than men, with no differences by family history status. Alcohol reduced sleep onset latency, sleep efficiency, and REM sleep while increasing wakefulness and Slow Wave Sleep across the entire night compared to placebo. Alcohol also generally increased sleep consolidation in the first half of the night, but decreased it during the second half. Sleepiness ratings were higher following alcohol, particularly in women at bedtime. Morning sleep quality ratings were lower following alcohol than placebo. Alcohol intoxication increases subjective sleepiness and disrupts sleep objectively more in healthy women than in men, with no differences evident by family history of alcoholism status. Evaluating moderators of alcohol effects on sleep may provide insight into the role of sleep in problem drinking.
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影响因子：
6
作者：
Howland, Jonathan;Rohsenow, Damaris J.;Hermos, John
通讯作者：
Hermos, John
影响因子：
10.5
作者：
Roehrs, T;Roth, T
通讯作者：
Roth, T
DOI：
10.15288/jsa.1982.43.434
发表时间：
1982-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
MACLEAN, AW;CAIRNS, J
通讯作者：
CAIRNS, J
影响因子：
5.6
作者：
GILLBERG, M;KECKLUND, G;AKERSTEDT, T
通讯作者：
AKERSTEDT, T
影响因子：
2.3
作者：
Dahl, RE;Williamson, DE;Ehlers, CL
通讯作者：
Ehlers, CL