Beyond calorie restriction: aging as a biological target for nutrient therapies.
Beyond calorie restriction: aging as a biological target for nutrient therapies.
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DOI：
10.1016/j.copbio.2020.11.008
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发表时间：
2021-08
影响因子：
7.7
通讯作者：
Hoffman JM
中科院分区：
文献类型：
--
作者：
Austad SN;Hoffman JM
可以说，迄今为止，衰老生物学中最重要的发现是，仅仅减少食物摄入就可以延长多种动物的寿命并改善其健康的许多方面。从前 50 年的啮齿动物食物限制研究中得出的传统观点包括：(1) 限制时间越长，限制对寿命的影响就越大；(2) 限制热量而不是任何特定的常量营养素对于其健康和长寿益处至关重要。然而，随着越来越多的限制研究对实验室啮齿动物以外的其他物种进行，这些假设开始崩溃。最近对苍蝇、啮齿动物、猴子以及越来越多的人类的研究已经开始解析热量限制、蛋白质限制、间歇性禁食和饮食时间模式如何影响食物限制对健康的益处。苍蝇研究不断提供信息，因为它一再表明基因型、年龄、性别、持续时间和节奏限制都会影响健康。最终，优化人类饮食将需要使用组学方法的个性化方法。
Arguably, the most important discovery in the biology of aging to date was that simply reducing food intake extended life and improved many aspects of health in a diversity of animal species. The conventional wisdom that emerged from first 50 years of rodent food restriction studies included (1) that the longevity impact of restriction was greater the longer restriction was imposed, and (2) that restricting calories rather than any specific macronutrient was critical to its health and longevity benefits. However these assumptions began to crumble as more and more restriction research was performed on other species besides laboratory rodents. Recent investigations of flies, rodents, monkeys, and increasingly humans, has begun to parse how calorie restriction, protein restriction, intermittent fasting, and the temporal pattern of eating all impact the health benefits of food restriction. Fly research continues to inform, as it has repeatedly shown that genotype, age, sex, duration, and tempo restriction all affect the health impact. Ultimately, optimizing human diets will require a personalized approach using omics approaches.
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卡路里不能通过果蝇饮食限制来解释寿命的延长。
影响因子：
9.8
作者：
Mair, William;Piper, Matthew D W;Partridge, Linda
通讯作者：
Partridge, Linda
影响因子：
64.8
作者：
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de Cabo, Rafael
影响因子：
29
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Longo VD
DOI：
10.1038/nrn.2017.156
发表时间：
2018-03
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
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通讯作者：
Cheng A
影响因子：
29
作者：
Mitchell SJ;Madrigal-Matute J;Scheibye-Knudsen M;Fang E;Aon M;González-Reyes JA;Cortassa S;Kaushik S;Gonzalez-Freire M;Patel B;Wahl D;Ali A;Calvo-Rubio M;Burón MI;Guiterrez V;Ward TM;Palacios HH;Cai H;Frederick DW;Hine C;Broeskamp F;Habering L;Dawson J;Beasley TM;Wan J;Ikeno Y;Hubbard G;Becker KG;Zhang Y;Bohr VA;Longo DL;Navas P;Ferrucci L;Sinclair DA;Cohen P;Egan JM;Mitchell JR;Baur JA;Allison DB;Anson RM;Villalba JM;Madeo F;Cuervo AM;Pearson KJ;Ingram DK;Bernier M;de Cabo R
通讯作者：
de Cabo R