Biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones.
Biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones.
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DOI：
10.1038/s41598-022-06267-8
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发表时间：
2022-02-15
影响因子：
4.6
通讯作者：
Dailey HL
中科院分区：
文献类型：
--
作者：
Inglis B;Schwarzenberg P;Klein K;von Rechenberg B;Darwiche S;Dailey HL
骨折通常通过形成一种称为骨痂的桥接结构来修复，骨痂最初是软组织，然后逐渐骨化，以恢复骨骼的刚性。虚拟力学测试是一种在临床前和临床环境下基于图像的结构骨愈合评估的很有前途的技术，但其准确性取决于用于分配组织力学特性的材料模型的有效性。本研究的目的是建立一种骨痂的本构模型，该模型能够反映骨痂的异质性和生物力学的二重性，骨痂包括软组织和编织骨。为了实现这一目标，对33只截骨绵羊在正常愈合和延迟愈合条件下的CT扫描得到的2363种三维有限元模型进行了大规模的优化分析。通过基于放射密度区分软性和硬性愈伤组织，确定了一种分段材料模型，该模型在虚拟和物理测试之间产生了高度的绝对一致性。结果表明，愈合的长骨的结构完整性是由间质软组织支持的矿化硬骨痂的内部结构所赋予的。这些发现表明，在适当的材料模型下，虚拟机械测试是物理生物力学测试的可靠替代。
Bone fractures commonly repair by forming a bridging structure called callus, which begins as soft tissue and gradually ossifies to restore rigidity to the bone. Virtual mechanical testing is a promising technique for image-based assessment of structural bone healing in both preclinical and clinical settings, but its accuracy depends on the validity of the material model used to assign tissue mechanical properties. The goal of this study was to develop a constitutive model for callus that captures the heterogeneity and biomechanical duality of the callus, which contains both soft tissue and woven bone. To achieve this, a large-scale optimization analysis was performed on 2363 variations of 3D finite element models derived from computed tomography (CT) scans of 33 osteotomized sheep under normal and delayed healing conditions. A piecewise material model was identified that produced high absolute agreement between virtual and physical tests by differentiating between soft and hard callus based on radiodensity. The results showed that the structural integrity of a healing long bone is conferred by an internal architecture of mineralized hard callus that is supported by interstitial soft tissue. These findings suggest that with appropriate material modeling, virtual mechanical testing is a reliable surrogate for physical biomechanical testing.
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影响因子：
9.7
作者：
Leong, P. L.;Morgan, E. F.
通讯作者：
Morgan, E. F.
影响因子：
2.4
作者：
Claes, LE;Heigele, CA
通讯作者：
Heigele, CA
影响因子：
5.3
作者：
Dailey, Hannah L.;Schwarzenberg, Peter;Harty, James A.
通讯作者：
Harty, James A.
DOI：
10.1002/cnm.3227
发表时间：
2019-07-11
影响因子：
2.1
作者：
Mora-Macias, Juan;Angel Giraldez-Sanchez, Miguel;Esther Reina-Romo, Maria
通讯作者：
Esther Reina-Romo, Maria
DOI：
10.1115/1.1688771
发表时间：
2004-04-01
影响因子：
1.7
作者：
Charlebois, M;McKee, MD;Buschmann, MD
通讯作者：
Buschmann, MD