ncRNAs-mediated high expression of TICRR promotes tumor cell proliferation and migration and is correlated with poor prognosis and tumor immune infiltration of hepatocellular carcinoma.
ncRNAs-mediated high expression of TICRR promotes tumor cell proliferation and migration and is correlated with poor prognosis and tumor immune infiltration of hepatocellular carcinoma.
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DOI：
10.1016/j.omtn.2022.09.007
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发表时间：
2022-12-13
期刊：
影响因子：
--
通讯作者：
Guleng, Bayasi
中科院分区：
文献类型：
--
作者：
He, Ke-Jie;Zhang, Yang-fan;Liang, Lai-ying;Cheng, Xiao-Shen;Gong, Guoyu;Ouyang, Xiao-Mei;Lin, Ying;Guleng, Bayasi
TICRR是与ToPBP1相互作用的DNA复制调控因子。目前，TICRR在LIHC中的潜在功能和机制尚不清楚。我们的目的是评估tirr在LIHC中的功能和预后。我们进行了LIHC中TICRR的差异表达分析、GO/KEGG和GSEA富集分析。我们还进行了TICRR的基因频率和SCNA分析。我们通过单因素和多因素分析发现，TICRR可以作为LIHC的独立预后指标。此外，我们观察到TICRR与免疫浸润有关，并且在LIHC中，TICRR与PD1/PD-L1和CTLA-4呈正相关。hsa-miR-126-3p/IPO9-AS1可能是调控TICRR表达的候选ncrna。TICRR的高SCNV率可能对LIHC中CTL细胞的功能有重要影响。我们通过一系列实验进一步证明，在体外，TICRR促进了肝癌细胞的增殖和转移。总之，TICRR可能是LIHC的潜在生物标志物和治疗靶点。通过单因素和多因素分析，TICRR可作为LIHC的独立预后指标；TICRR与免疫浸润有关。在体外，TICRR促进肝癌细胞的增殖和转移。hsa-miR-126-3p/IPO9-AS1可能是调控TICRR表达的候选ncrna。TICRR可能是LIHC潜在的生物标志物和治疗靶点。
TICRR is a regulatory factor of DNA replication with ToPBP1 interaction. At present, the underlying function and mechanisms of TICRR remain unclear in LIHC. Our objective was to assess the function and prognosis of TICRR in LIHC. We conducted a differential expression analysis, GO/KEGG, and GSEA enrichment analysis of TICRR in LIHC. We also carried out the gene frequency and SCNA of TICRR. We found that TICRR could serve as an independent prognostic marker in LIHC by univariate and multivariate analysis. In addition, we observed that TICRR was related to immune infiltration, and TICRR had positive correlation with PD1/PD-L1 and CTLA-4 in LIHC. The hsa-miR-126-3p/IPO9-AS1 may be the candidate ncRNAs to regulate the expression of TICRR. The high rate of SCNV of TICRR might have critical effect on the function of CTL cells in LIHC. We further demonstrate through a series of experiments that TICRR facilitated the proliferation and metastasis of liver cancer cells in vitro. Altogether, TICRR might be a potential biomarker and therapeutic target in LIHC. TICRR could serve as an independent prognostic marker in LIHC by univariate and multivariate analysis; TICRR was related to immune infiltration. TICRR facilitated the proliferation and metastasis of liver cancer cells in vitro. The hsa-miR-126-3p/IPO9-AS1 may be the candidate ncRNAs to regulate the expression of TICRR. TICRR might be a potential biomarker and therapeutic target in LIHC.
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