Impact of maternal diabetes on birthweight is greater in non-Hispanic blacks than in non-Hispanic whites.
Impact of maternal diabetes on birthweight is greater in non-Hispanic blacks than in non-Hispanic whites.
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DOI：
10.1007/s00125-011-2430-z
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发表时间：
2012-04
期刊：
影响因子：
8.2
通讯作者：
Korte, J. E.
中科院分区：
文献类型：
--
作者：
Hunt, K. J.;Marlow, N. M.;Gebregziabher, M.;Ellerbe, C. N.;Mauldin, J.;Mayorga, M. E.;Korte, J. E.
关键词：
确定妊娠期母亲糖尿病对胎儿生长种族差异的影响。使用关联的出生证明、住院医院和产前索赔数据，我们检查了南卡罗来纳州居民母亲的活单胎出生，这些母亲自报其种族为非西班牙裔白色（NHW，140128）或非西班牙裔黑人（NHB，82492），并在2004年至2008年胎龄28至42周分娩。NHB的孕前糖尿病患病率（3.0%）高于NHW（1.7%），而NHB（6.1%）和NHW（6.3%）的妊娠期糖尿病（GDM）患病率相似。在分娩BMI为35 kg/m2时，GDM暴露与NHW的平均出生体重仅增加17 g（95% CI：4，30），但NHB的平均出生体重增加78 g（95% CI：61，95）（控制胎龄，母亲年龄，婴儿性别和产前护理信息）。NHWs和NHBs中的孕前糖尿病数量分别为58克（95% CI：34，81）和60克（95% CI：37，84）。GDM对NHB的出生体重的影响大于NHW [60 g种族差异（95% CI：39，82）]，而孕前糖尿病的影响很大，但相似。同样，NHW组中相对于正常胎龄体重的婴儿，GDM的风险比[RR=1.41（95%CI：1.34，1.49）]低于NHB组[RR= 2.24（95%CI：2.05，2.46）]。这些数据表明，妊娠期糖尿病合并肥胖的负面影响可能是更大的NHB比NHW个人。
To determine the impact of maternal diabetes during pregnancy on racial disparities in fetal growth. Using linked birth certificate, inpatient hospital and prenatal claims data we examined live singleton births of South Carolina resident mothers, who self-reported their race as non-Hispanic white (NHW, 140128) or non-Hispanic black (NHB, 82492) and delivered at 28 to 42 weeks gestational age 2004 through 2008. Pre-pregnancy diabetes prevalence was higher in NHB (3.0%) than NHW (1.7%), while gestational diabetes (GDM) prevalence was similar in NHB (6.1%) and NHW (6.3%). At a delivery BMI of 35 kg/m2, GDM exposure was associated with an average birthweight only 17 grams (95% CI: 4, 30) higher in NHW, but 78 grams (95% CI: 61, 95) higher in NHBs (controlling for gestational age, maternal age, infant sex, and having information on prenatal care). Numbers for pre-pregnancy diabetes were 58 grams (95% CI: 34, 81) in NHWs and 60 grams (95% CI: 37, 84) in NHBs. GDM had a greater impact on birthweight in NHBs than on NHWs [60 gram racial difference (95 % CI: 39, 82)], while pre-pregnancy diabetes had a large but similar impact. Similarly, the risk ratio for GDM of having a large relative to a normal weight for gestational age infant was lower in NHW [RR=1.41 (95% CI: 1.34, 1.49)] than in NHB [RR= 2.24 (95% CI: 2.05, 2.46)] women. These data suggest that the negative effects of GDM combined with obesity during pregnancy may be greater in NHB than NHW individuals.
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