Integrated Review of the Assessment of Newborns With Neonatal Abstinence Syndrome.
Integrated Review of the Assessment of Newborns With Neonatal Abstinence Syndrome.
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DOI：
10.1016/j.jogn.2021.04.014
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Cong X
中科院分区：
文献类型：
--
作者：
Casavant SG;Meegan T;Fleming M;Hussain N;Gork S;Cong X
对目前有关新生儿禁欲综合征(NAS)评估的知识进行批判性回顾和总结。我们检索了以下数据库，并限定文章语言种类为English，分别为：PubMed，CINAHL，和ousinfo，并限定文章语言种类为English。用于确定相关研究文章的关键词和网状术语包括新生儿禁欲综合征；芬尼根量表；饮食、睡眠、控制台；表观遗传学；遗传学；药代动力学；以及测量。我们独立审阅了收录的文章。通过数据库检索435篇，人工参考文献检索17篇，纳入终审文献31篇。排除的文章是重复的，与NAS无关，定性研究，和/或质量低。我们使用了Whittemore和Knafl的方法来指导这次综合审查。我们提取并组织了以下标题下的数据：作者、年份和国家、目的、研究设计、参与者、测量、生物标记物(如果适用)、结果、限制、建议和干预。芬尼根新生儿禁欲量表是衡量新生儿NAS症状的最广泛使用的工具，尽管它具有高度的主观性。最近，从芬尼肯新生儿戒断量表过渡到饮食、睡眠、安慰方法，该方法包括结构化评估和干预，并已被证明可以减少住院时间和阿片类药物治疗总剂量。研究人员检测了NAS的生物标记物，包括遗传标记物和自主神经系统对NAS发病率和不同严重程度的反应。在纳入的文章中，患有阿片类药物使用障碍的妇女在怀孕期间接受纳曲酮治疗后生下了没有NAS诊断的新生儿。然而，大多数接受丁丙诺啡治疗的妇女生下的新生儿都被诊断为NAS。新生儿禁欲综合症以多种方式对新生儿产生负面影响，对新生儿戒断反应的客观评估和衡量仍未得到充分研究，需要进一步调查。新生儿禁欲综合征对新生儿有负面影响。有许多方法可以减少症状、药物的使用和住院时间。
To critically review and summarize current knowledge regarding the assessment of newborns with neonatal abstinence syndrome (NAS). We searched the following databases for articles on the assessment of newborns with NAS that were published in English between January 2014 and June 2020: PubMed, CINAHL, and PsychINFO. Keywords and MeSH terms used to identify relevant research articles included neonatal abstinence syndrome; Finnegan Scale; Eat, Sleep, Console; epigenetics; genetics; pharmacokinetics; and measurement. We independently reviewed articles for inclusion. We retrieved 435 papers through database searches and 17 through manual reference searches; 31 articles are included in the final review. Excluded articles were duplicates, not relevant to NAS, qualitative studies, and/or of low quality. We used the methodology of Whittemore and Knafl to guide this integrative review. We extracted and organized data under the following headings: author, year and country, purpose, study design, participants, measurement, biomarker (if applicable), results, limitations, recommendations, and intervention. The Finnegan Neonatal Abstinence Scale is the most widely used instrument to measure symptoms of NAS in newborns, although it is highly subjective. Recently there has been a transition from the Finnegan Neonatal Abstinence Scale to the Eat, Sleep, Console method, which consists of structured assessment and intervention and has been shown to decrease length of hospital stay and total opioid treatment dose. Researchers examined biomarkers of NAS, including genetic markers and autonomic nervous system responses on the variation in incidence and differential severity of NAS. In the included articles, women with opioid use disorder who were treated with naltrexone during pregnancy gave birth to newborns without NAS diagnoses. However, most women who were treated with buprenorphine gave birth to newborns with NAS diagnoses. Neonatal abstinence syndrome negatively affects newborns in a multitude of ways, and the objective assessment and measurement of the newborn’s response to withdrawal remains understudied and needs further investigation. Neonatal abstinence syndrome has a negative effect on newborns. There are many methods to reduce symptoms, use of medication, and length of stay.
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影响因子：
1.8
作者：
Fanaei, Hamed;Riki, Farideh;Bornavard, Morad
通讯作者：
Bornavard, Morad
影响因子：
158.5
作者：
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通讯作者：
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影响因子：
2.2
作者：
Heller NA;Logan BA;Morrison DG;Paul JA;Brown MS;Hayes MJ
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影响因子：
26.1
作者：
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通讯作者：
Talbert JC
影响因子：
8
作者：
Hall, Eric S.;Wexelblatt, Scott L.;Walsh, Michele C.
通讯作者：
Walsh, Michele C.