Neonatal abstinence syndrome: Neurobehavior at 6 weeks of age in infants with or without pharmacological treatment for withdrawal.

Neonatal abstinence syndrome: Neurobehavior at 6 weeks of age in infants with or without pharmacological treatment for withdrawal.
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DOI:
10.1002/dev.21532
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发表时间:
2017-07
影响因子:
2.2
通讯作者:
Hayes MJ
Hayes MJ
中科院分区:
心理学4区
文献类型:
--
作者:
Heller NA;Logan BA;Morrison DG;Paul JA;Brown MS;Hayes MJ

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处方阿片类药物的使用和滥用以及随之而来的新生儿戒断综合症 (NAS) 的增加,自 2000 年以来增加了两倍,这种情况可能导致超过 60% 的婴儿需要长期药物治疗。这项研究使用 NICU 网络神经行为量表评估了产前美沙酮暴露的六周大婴儿的神经行为发育,这些婴儿有(NAS+;n=23)或没有(NAS−;n=23)。 n=16) 需要根据芬尼根量表确定的 NAS 严重程度进行药物治疗。一组未暴露的、人口统计学相似且年龄匹配的婴儿作为比较(COMP;n=21)。 NAS+组(而非NAS−组)在调节(p<.01)和运动质量(p<.01)总结量表上的得分显着低于COMP组。 NAS+ 和 NAS− 组在压力节制量表上的得分高于 COMP 组 (p<.05)。与同一人群中没有产前美沙酮暴露的婴儿相比,NAS 诊断 (NAS+) 与六周龄时较差的运动调节和质量相关。
Use and abuse of prescription opioids and concomitant increase in Neonatal Abstinence Syndrome (NAS), a condition that may lead to protracted pharmacological treatment in more than 60% of infants, has tripled since 2000. This study assessed neurobehavioral development using the NICU Network Neurobehavioral Scale in six-week old infants with prenatal methadone exposure who did (NAS+; n=23) or did not (NAS−; n=16) require pharmacological treatment for NAS severity determined by Finnegan Scale. An unexposed, demographically similar group of infants matched for age served as comparison (COMP; n=21). NAS+, but not NAS− group, had significantly lower scores on the regulation (p<.01) and quality of movement (p<.01) summary scales than the COMP group. The NAS+ and NAS− groups had higher scores on the stress-abstinence scale than the COMP group (p<.05). NAS diagnosis (NAS+) was associated with poorer regulation and quality of movement at six weeks of age compared to infants without prenatal methadone exposure from the same demographic.
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