Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus.
Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus.
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DOI：
10.1002/hipo.20860
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发表时间：
2012-01
期刊：
影响因子：
3.5
通讯作者：
Gordon, Joshua A.
中科院分区：
文献类型：
--
作者：
Lacefield, Clay O.;Itskov, Vladimir;Reardon, Thomas;Hen, Rene;Gordon, Joshua A.
关键词：
在大多数哺乳动物的成年过程中，海马结构的齿状回不断产生新的神经元。最近的工作已经证明了特定的认知缺陷后，消除成年海马神经发生在啮齿动物，这表明这些神经元可能有助于海马回路中的信息处理。年轻的成年出生的神经元表现出增强的兴奋性，并在体外海马切片制备突触可塑性的能力改变。然而，关于成年出生的颗粒细胞对体内海马活动的影响知之甚少。为了评估这些新的神经元的影响，在齿状回的神经回路，我们记录了贯穿路径诱发反应和自发网络活动的海马已被局部X射线照射，以消除人口的年轻的成年出生的颗粒细胞的海马麻醉小鼠的齿状回。X射线照射后，穿孔路径反应的幅度减少。与此相反，有一个显着的增加，在齿状回和门的自发伽玛频率爆发的幅度，以及增加同步的齿状神经元放电这些突发。在使用GFAP：TK药物遗传学消融技术消除成体神经发生的动物中也发现了类似的伽马爆发振幅增加。这些数据表明，年轻的神经元可能会抑制或破坏齿状核和门区的经常性网络活动。这一意想不到的结果产生了一个新的观点，即适度数量的年轻成人产生的颗粒细胞如何调节较大群体的成熟颗粒细胞的活性，而不是仅仅作为独立的编码单位。
Throughout the adult life of most mammals, new neurons are continuously generated in the dentate gyrus of the hippocampal formation. Recent work has documented specific cognitive deficits after elimination of adult hippocampal neurogenesis in rodents, suggesting that these neurons may contribute to information processing in hippocampal circuits. Young adult-born neurons exhibit enhanced excitability and have altered capacity for synaptic plasticity in hippocampal slice preparations in vitro. Still, little is known about the effect of adult-born granule cells on hippocampal activity in vivo. In order to assess the impact of these new neurons on neural circuits in the dentate, we recorded perforant-path evoked responses and spontaneous network activity from the dentate gyrus of urethane-anesthetized mice whose hippocampus had been focally X-irradiated to eliminate the population of young adult-born granule cells. After X-irradiation, perforant-path responses were reduced in magnitude. In contrast, there was a marked increase in the amplitude of spontaneous gamma-frequency bursts in the dentate gyrus and hilus, as well as increased synchronization of dentate neuron firing to these bursts. A similar increase in gamma burst amplitude was also found in animals in which adult neurogenesis was eliminated using the GFAP:TK pharmacogenetic ablation technique. These data suggest that young neurons may inhibit or destabilize recurrent network activity in the dentate and hilus. This unexpected result yields a new perspective on how a modest number of young adult–generated granule cells may modulate activity in the larger population of mature granule cells, rather than acting solely as independent encoding units.
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影响因子：
3.7
作者：
Mongiat LA;Espósito MS;Lombardi G;Schinder AF
通讯作者：
Schinder AF
DOI：
10.1073/pnas.0702164104
发表时间：
2007-05-01
影响因子：
11.1
作者：
Mori, Masahiro;Gahwiler, Beat H.;Gerber, Urs
通讯作者：
Gerber, Urs
影响因子：
16.2
作者：
Isomura, Yoshikazu;Sirota, Anton;Buzsaki, Gyoergy
通讯作者：
Buzsaki, Gyoergy
DOI：
10.1523/jneurosci.5218-08.2009
发表时间：
2009-02-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bogaard A;Parent J;Zochowski M;Booth V
通讯作者：
Booth V
海马网络活性通过诱导自由行为大鼠的齿状回的长期增强而瞬时改变。
影响因子：
3
作者：
通讯作者：
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