Obese asthma phenotypes display distinct plasma biomarker profiles.
Obese asthma phenotypes display distinct plasma biomarker profiles.
复制标题
肥胖的哮喘表型显示出不同的等离子体生物标志物谱。
DOI：
10.1002/clt2.12238
复制
发表时间：
2023-03
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
作者：
肥胖性哮喘是一种复杂的表型，需要进一步的病理生理特征。本研究旨在探索瘦型和超重/肥胖型哮喘患者的炎症相关血浆生物标志物。我们使用2069名24 - 26岁奥尔兹的数据，在基于人群的队列BAMSE（瑞典：儿童，过敏，环境，斯德哥尔摩，流行病学）中阐明了肥胖哮喘表型中炎症相关血浆蛋白的水平。受试者被分为瘦型哮喘（n = 166）、瘦型对照（n = 1440）、超重/肥胖哮喘（n = 73）和超重/肥胖对照（n = 390）。使用Olink Proseek多重炎症组分析蛋白质水平（n = 92）。在92种蛋白质中，41种与瘦型和/或超重/肥胖型哮喘相关。大多数与超重/肥胖哮喘相关的蛋白质也与非哮喘患者的超重/肥胖相关。β神经生长因子（BetaNGF）、白细胞介素10（IL-10）和基质金属蛋白酶10（MMP-10）仅与瘦型哮喘相关，而C-C基序趋化因子20（CCL-20）、成纤维细胞生长因子19（FGF-19）、白细胞介素5（IL-5）、白血病抑制因子（LIF）、肿瘤坏死因子配体超家族成员9（TNFRSF 9）、和尿激酶型纤溶酶原激活物（uPA）仅与超重/肥胖哮喘相关。超重/肥胖改变了哮喘与3种蛋白质之间的关系：成纤维细胞生长因子21（FGF 21），白细胞介素4（IL-4）和尿激酶型纤溶酶原激活物（uPA）。在超重/肥胖组中，白细胞介素-6（IL-6）与非过敏性哮喘相关，但与过敏性哮喘无关。这些数据表明，不同的血浆蛋白表型瘦和超重/肥胖哮喘，这反过来又会影响治疗方法。
Obese asthma is a complex phenotype and further characterization of the pathophysiology is needed. This study aimed to explore inflammation‐related plasma biomarkers in lean and overweight/obese asthmatics. We elucidated levels of inflammation‐related plasma proteins in obese asthma phenotypes in the population‐based cohort BAMSE (Swedish: Children, Allergy, Milieu, Stockholm, Epidemiology) using data from 2069 24‐26‐year‐olds. Subjects were divided into lean asthma (n = 166), lean controls (n = 1440), overweight/obese asthma (n = 73) and overweight/obese controls (n = 390). Protein levels (n = 92) were analysed using the Olink Proseek Multiplex Inflammation panel. Of the 92 included proteins, 41 were associated with lean and/or overweight/obese asthma. The majority of proteins associated with overweight/obese asthma also associated with overweight/obesity among non‐asthmatics. Beta‐nerve growth factor (BetaNGF), interleukin 10 (IL‐10), and matrix metalloproteinase 10 (MMP10) were associated only with lean asthma while C‐C motif chemokine 20 (CCL20), fibroblast growth factor 19 (FGF19), interleukin 5 (IL‐5), leukemia inhibitory factor (LIF), tumor necrosis factor ligand superfamily member 9 (TNFRSF9), and urokinase‐type plasminogen activator (uPA) were associated only with overweight/obese asthma. Overweight/obesity modified the association between asthma and 3 of the proteins: fibroblast growth factor 21 (FGF21), interleukin 4 (IL‐4), and urokinase‐type plasminogen activator (uPA). In the overweight/obese group, interleukin‐6 (IL‐6) was associated with non‐allergic asthma but not allergic asthma. These data indicate distinct plasma protein phenotypes in lean and overweight/obese asthmatics which, in turn, can impact upon therapeutic approaches.
登录
查看更多内容
3-95 岁年龄范围的多种族肺活量测定参考值：2012 年全球肺功能方程。
DOI：
10.1183/09031936.00080312
发表时间：
2012-12
期刊：
The European respiratory journal
影响因子：
--
作者：
Quanjer PH;Stanojevic S;Cole TJ;Baur X;Hall GL;Culver BH;Enright PL;Hankinson JL;Ip MS;Zheng J;Stocks J;ERS Global Lung Function Initiative
通讯作者：
ERS Global Lung Function Initiative
影响因子：
14.2
作者：
Lugogo, Njira;Green, Cynthia L.;Kraft, Monica
通讯作者：
Kraft, Monica
DOI：
10.1016/j.jaci.2018.02.004
发表时间：
2018-04
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Peters U;Dixon AE;Forno E
通讯作者：
Forno E
DOI：
10.1073/pnas.1920004117
发表时间：
2020-02-11
影响因子：
11.1
作者：
Han, Myoung Sook;White, Alexis;Davis, Roger J.
通讯作者：
Davis, Roger J.
影响因子：
6.1
作者：
Scott, H. A.;Gibson, P. G.;Wood, L. G.
通讯作者：
Wood, L. G.