The association between Barrett's esophagus and Helicobacter pylori infection: a meta-analysis.
The association between Barrett's esophagus and Helicobacter pylori infection: a meta-analysis.
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DOI：
10.1111/j.1523-5378.2011.00931.x
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发表时间：
2012-06
期刊：
影响因子：
4.4
通讯作者：
El-Serag HB
中科院分区：
文献类型：
--
作者：
Fischbach LA;Nordenstedt H;Kramer JR;Gandhi S;Dick-Onuoha S;Lewis A;El-Serag HB
幽门螺杆菌对巴雷特食管的影响知之甚少。我们进行了一项荟萃分析，以总结现有的文献检查幽门螺杆菌对巴雷特食管的影响。我们进行了全面的检索，以确定幽门螺杆菌和巴雷特食管之间的关联的研究。我们进行了荟萃回归分析，以确定幽门螺杆菌对巴雷特食管的影响的变化来源。我们的分析总共包括49项检查幽门螺杆菌对巴雷特食管影响的研究和7项检查cag A阳性对巴雷特食管影响的研究。总的来说，在大多数研究中，幽门螺杆菌，甚至cag A，往往对巴雷特食管有保护作用;然而，研究之间存在明显的异质性。幽门螺杆菌对巴雷特食管的影响因地理位置和存在选择和信息偏差而异。只有4项研究没有发现明显的选择和信息偏倚，这些研究显示了幽门螺杆菌对Barrett食管的保护作用（相对风险= 0.46 [95%CI：0.35，0.60]）。幽门螺杆菌对Barrett食管影响的估计值在不同研究中存在异质性。我们确定选择和信息偏差作为这种异质性的潜在来源。很少有没有明显的选择和信息偏差的研究已经进行了检查幽门螺杆菌对巴雷特食管的影响，但在这些研究中，幽门螺杆菌感染与巴雷特食管的风险降低。
The effect of Helicobacter pylori on Barrett’s esophagus is poorly understood. We conducted a meta-analysis to summarize the existing literature examining the effect that H pylori has on Barrett’s esophagus. We performed a comprehensive search to identify studies pertaining to the association between H pylori and Barrett’s esophagus. We conducted meta-regression analyses to identify sources of variation in the effect of H pylori on Barrett’s esophagus. Our analysis included a total of 49 studies that examined the effect of H pylori on Barrett’s esophagus and 7 studies that examined the effect of cag A positivity on Barrett’s esophagus. Overall, H pylori, and even more so cag A, tended to be protective for Barrett’s esophagus in most studies; however there was obvious heterogeneity across studies. The effect of H pylori on Barrett’s esophagus varied by geographic location and in the presence of selection and information biases. Only 4 studies were found without obvious selection and information bias, and these showed a protective effect of H pylori on Barrett’s esophagus (Relative Risk = 0.46 [95% CI: 0.35, 0.60]). Estimates for the effect of H pylori on Barrett’s esophagus were heterogeneous across studies. We identified selection and information bias as potential sources of this heterogeneity. Few studies without obvious selection and information bias have been conducted to examine the effect of H pylori on Barrett’s esophagus, but in these, H pylori infection is associated with a reduced risk of Barrett’s esophagus.
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影响因子：
2.4
作者：
Ferrández A;Benito R;Arenas J;García-González MA;Sopeña F;Alcedo J;Ortego J;Sainz R;Lanas A
通讯作者：
Lanas A
DOI：
10.1097/00005176-199711000-00004
发表时间：
1997-11-01
影响因子：
2.9
作者：
Goodman, KJ;Correa, P;Collazos, T
通讯作者：
Collazos, T
影响因子：
4.7
作者：
Flood, V. M.;Burlutsky, G.;Mitchell, P.
通讯作者：
Mitchell, P.
影响因子：
24.5
作者：
Hackelsberger, A;Günther, T;Malfertheiner, P
通讯作者：
Malfertheiner, P
影响因子：
9.8
作者：
El-Serag, HB;Sonnenberg, A;Feddersen, RM
通讯作者：
Feddersen, RM