Amphetamine-induced appetitive 50-kHz calls in rats: a marker of affect in mania?
Amphetamine-induced appetitive 50-kHz calls in rats: a marker of affect in mania?
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安非他明引起的大鼠食欲 50 kHz 叫声：躁狂症影响的标志？
DOI：
10.1007/s00213-013-3413-1
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发表时间：
2014
影响因子：
3.4
通讯作者：
Schwarting RKW
中科院分区：
文献类型：
--
作者：
Pereira M;Brenes JC;Andreatini R;Schwarting RKW
旨在模拟躁狂的动物模型的共同点是缺乏真正的情感参数。虽然啮齿类动物苯丙胺诱导的过度运动是一种常用的躁狂行为模型，但运动活动是开发新药物治疗的非特异性靶点，并不一定构成双相情感障碍（BD）的主要症状。因此，替代的行为标记敏感的兴奋剂是必要的。ObjectivesSince苯丙胺诱导食欲50 kHz超声发声（USV）在大鼠，我们问是否建立或潜在的抗躁狂药物会抑制这种作用，从而可能补充传统的分析自发活动。（2.5mg/kg）与抗躁狂药物锂（100 mg/kg）和他莫昔芬（1 mg/kg）一起全身给药。由于蛋白激酶C（PKC）的活性已牵连在双相情感障碍的病理生理学和情绪稳定剂的生化作用，新的PKC抑制剂杨梅苷（10，30毫克/公斤）也evaluated.ResultsWe首次证明，已知的或潜在的抗躁狂活性的药物是有效的扭转安非他明诱导的食欲50 kHz的电话。治疗特别是正常安非他明诱导的增加调频电话，一个亚型大概表示积极的影响rat.ConclusionsOur的研究结果表明，安非他明诱导的50 kHz的电话可能构成一个标志，为沟通的影响，提供了一个有用的模型夸张的欣快情绪和压力的讲话。PKC抑制剂他莫昔芬和杨梅苷的抗躁狂样作用支持这两种药物在该模型中的预测和病因学有效性，并突出了PKC信号传导作为治疗躁狂症和精神病相关疾病的有希望的靶点的作用。
RationaleAnimal models aimed to mimic mania have in common the lack of genuine affective parameters. Although rodent amphetamine-induced hyperlocomotion is a frequently used behavioral model of mania, locomotor activity is a rather unspecific target for developing new pharmacological therapies, and does not necessarily constitute a cardinal symptom in bipolar disorder (BD). Hence, alternative behavioral markers sensitive to stimulants are required.ObjectivesSinced-amphetamine induces appetitive 50-kHz ultrasonic vocalizations (USV) in rats, we asked whether established or potential antimanic drugs would inhibit this effect, thereby possibly complementing traditional analysis of locomotor activity.MethodsAmphetamine-treated rats (2.5 mg/kg) were systemically administered with the antimanic drugs lithium (100 mg/kg) and tamoxifen (1 mg/kg). Since protein kinase C (PKC) activity has been implicated in the pathophysiology of bipolar disorder and the biochemical effects of mood stabilizers, the new PKC inhibitor myricitrin (10, 30 mg/kg) was also evaluated.ResultsWe demonstrate for the first time that drugs with known or potential antimanic activity were effective in reversing amphetamine-induced appetitive 50-kHz calls. Treatments particularly normalized amphetamine-induced increases of frequency-modulated calls, a subtype presumably indicative of positive affect in the rat.ConclusionsOur findings suggest that amphetamine-induced 50-kHz calls might constitute a marker for communicating affect that provides a useful model of exaggerated euphoric mood and pressured speech. The antimanic-like effects of the PKC inhibitors tamoxifen and myricitrin support the predictive and etiological validity of both drugs in this model and highlight the role of PKC signaling as a promising target to treat mania and psychosis-related disorders.
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影响因子：
3.6
作者：
Natusch, C.;Schwarting, R. K. W.
通讯作者：
Schwarting, R. K. W.
影响因子：
2.6
作者：
Brudzynski, SM
通讯作者：
Brudzynski, SM
蛋白激酶 C 抑制剂可阻断大鼠纹状体切片中苯丙胺介导的多巴胺释放。
DOI：
--
发表时间：
1998
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Kantor,L;Gnegy,ME
通讯作者：
Gnegy,ME
他莫昔芬的抗躁狂样作用：与其他 PKC 抑制药物和抗雌激素药物的行为比较
影响因子：
5.6
作者：
P. Sabioni;I. P. Baretta;E. M. Ninomiya;Lianna Gustafson;A. Rodrigues;R. Andreatini
通讯作者：
R. Andreatini
碳酸锂处理减弱 d- 和 l-苯丙胺的欣快感和激活作用
DOI：
--
发表时间：
1975
期刊：
Psychopharmacologia
影响因子：
--
作者：
D. Kammen;D. Murphy
通讯作者：
D. Murphy