Spatially Controlled Templated Hydrogels for Orthopedic Interfacial Tissue Regeneration.
Spatially Controlled Templated Hydrogels for Orthopedic Interfacial Tissue Regeneration.
复制标题
用于骨科界面组织再生的空间控制模板化水凝胶。
作者：
Michael T. Frassica;Connor J Demott;E. M. Ramírez;M. Grunlan
重现骨科界面组织空间复杂性的支架是骨科界面组织再生的关键。这需要一种容易和灵活地制造具有对物理和化学性质的空间控制的支架的方法，而不会导致硬界面。在这里，我们制备了具有空间可调排列和化学成分的水凝胶支架(SSTAC)。使用溶剂诱导相分离/熔盐模板(SiPS/盐)，最初制备的支架元素具有可调节的孔径并与一个或多个紫外光反应性大分子单体一起制备。在修剪到所需尺寸后，对这些进行物理配置并将其融合在一起，以形成SSTAC。使用这种方法，准备了三种SSTAC设计，其中一种模仿了骨软骨界面。明场/荧光显微镜显示，无论层的组成如何，孔大小和化学成分都可以在相对平滑和完整的界面上进行空间控制。由SSTAC形成的界面被确定为承受与没有界面的类似支架相似的剪切力。
Scaffolds that recapitulate the spatial complexity of orthopedic interfacial tissues are essential to their regeneration. This requires a method to readily and flexibly produce scaffolds with spatial control over physical and chemical properties, without resulting in hard interfaces. Herein, we produced hydrogel scaffolds with spatially tunable arrangements and chemistries (SSTACs). Using solvent-induced phase separation/fused salt templating (SIPS/salt), scaffold elements are initially prepared with a tunable pore size and with one or more UV-reactive macromers. After trimming to the desired dimensions, these are physically configured and fused together to form the SSTACs. Using this method, three SSTAC designs were prepared, including one that mimicked the osteochondral interface. Bright-field/fluorescent microscopy revealed spatial control of pore size and chemical composition across a relatively smooth and integrated interface, regardless of layer composition. An interface formed by a SSTAC was determined to withstand a similar shear force to an analogous scaffold with no interface.
影响因子：
41.2
作者：
通讯作者：
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影响因子：
9.7
作者：
Frassica, Michael T.;Jones, Sarah K.;Grunlan, Melissa A.
通讯作者：
Grunlan, Melissa A.
影响因子：
9.7
作者：
Bailey BM;Fei R;Munoz-Pinto D;Hahn MS;Grunlan MA
通讯作者：
Grunlan MA