PDMS(star)-PEG hydrogels prepared via solvent-induced phase separation (SIPS) and their potential utility as tissue engineering scaffolds.
PDMS(star)-PEG hydrogels prepared via solvent-induced phase separation (SIPS) and their potential utility as tissue engineering scaffolds.
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DOI：
10.1016/j.actbio.2012.07.034
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发表时间：
2012-12
影响因子：
9.7
通讯作者：
Grunlan MA
中科院分区：
文献类型：
--
作者：
Bailey BM;Fei R;Munoz-Pinto D;Hahn MS;Grunlan MA
通过溶剂诱导相分离（SIPS）制备了基于甲基丙烯酸酯化星形聚二甲基硅氧烷（PDMSstar-MA）和二丙烯酸酯化聚（乙二醇）（PEG-DA）大分子单体的无机-有机水凝胶。将大分子单体合并在二氯甲烷（DCM）前体溶液中，并依次进行光聚合、干燥和水合。通过改变 PEG-DA 的数均分子量 (Mn) (Mn = 3.4k 和 6k g/mol) 以及 PDMSstar-MA (Mn = 7k g/mol) 与 PEG-DA 的重量百分比 (wt%) 比例从 0:100 到 20:80，进一步定制水凝胶的化学和物理性质。与由水性前体溶液制备的类似水凝胶相比，SIPS 生产的水凝胶具有大孔形态、PDMSstar-MA 分布更均匀、模量增加和降解速率提高。表征了水凝胶的形态、溶胀率、机械性能、生物活性、非特异性蛋白质粘附、细胞粘附的受控引入和细胞相容性。由于其可调特性，该水凝胶库可用于研究材料引导的细胞行为和最终组织再生。
Inorganic-organic hydrogels based on methacrylated star polydimethylsiloxane (PDMSstar-MA) and diacrylated poly(ethylene glycol) (PEG-DA) macromers were prepared via solvent-induced phase separation (SIPS). The macromers were combined in a dichloromethane (DCM) precursor solution and sequentially photopolymerized, dried and hydrated. The chemical and physical properties of the hydrogels were further tailored by varying the number average molecular weight (Mn) of PEG-DA (Mn = 3.4k and 6k g/mol) as well as the weight % (wt%) ratio of PDMSstar-MA (Mn = 7k g/mol) to PEG-DA from 0:100 to 20:80. Compared to analogous hydrogels fabricated from aqueous precursor solutions, SIPS produced hydrogels with a macroporous morphology, a more even distribution of PDMSstar-MA, increased modulus and enhanced degradation rates. The morphology, swelling ratio, mechanical properties, bioactivity, non-specific protein adhesion, controlled introduction of cell-adhesion, and cytocompatibility of the hydrogels were characterized. As a result of their tunable properties, this library of hydrogels is useful to study material-guided cell behavior and ultimate tissue regeneration.
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影响因子：
3
作者：
Chiu, Yu-Chieh;Larson, Jeffery C.;Brey, Eric M.
通讯作者：
Brey, Eric M.
影响因子：
--
作者：
Gudipati, CS;Greenlief, CM;Wooley, KL
通讯作者：
Wooley, KL
影响因子：
14
作者：
Crouch, Adam S.;Miller, D.;Hu, W.
通讯作者：
Hu, W.
影响因子：
6.2
作者：
Hou, Yaping;Schoener, Cody A.;Regan, Katherine R.;Munoz-Pinto, Dany;Hahn, Mariah S.;Grunlan, Melissa A.
通讯作者：
Grunlan, Melissa A.
影响因子：
41.2
作者：
通讯作者：
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