Engineering multicellular living systems-a Keystone Symposia report.
Engineering multicellular living systems-a Keystone Symposia report.
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DOI：
10.1111/nyas.14896
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发表时间：
2022-12
影响因子：
5.2
通讯作者：
Mulero-Russe, Adriana
中科院分区：
文献类型：
--
作者：
Cable, Jennifer;Arlotta, Paola;Parker, Kevin Kit;Hughes, Alex J.;Goodwin, Katharine;Mummery, Christine L.;Kamm, Roger D.;Engle, Sandra J.;Tagle, Danilo A.;Boj, Sylvia F.;Stanton, Alice E.;Morishita, Yoshihiro;Kemp, Melissa L.;Norfleet, Dennis A.;May, Elebeoba E.;Lu, Aric;Bashir, Rashid;Feinberg, Adam W.;Hull, Sarah M.;Gonzalez, Anjelica L.;Blatchley, Michael R.;Pulido, Nuria Montserrat;Morizane, Ryuji;McDevitt, Todd C.;Mishra, Deepak;Mulero-Russe, Adriana
设计复杂的多细胞系统的能力具有巨大的潜力，可以告知我们对生物过程和疾病的理解，并改变药物开发过程。工程生命系统来模拟自然过程或纳入新的功能依赖于对细胞之间、细胞之间及其环境之间的生化、机械和其他线索的详细了解，这些线索导致多细胞系统的协调行动。2022年4月3日至6日，该领域的专家在Keystone研讨会“工程多细胞生命系统”上会面，讨论了在理解细胞如何在多细胞系统中合作方面的最新进展，以及最近在芯片上器官模型、生物机器人和类器官等工程系统方面的努力。鉴于两者的相似之处和共同的主题，本次会议与“类器官作为基础发现和翻译的工具”研讨会同时举行。
The ability to engineer complex multicellular systems has enormous potential to inform our understanding of biological processes and disease and alter the drug development process. Engineering living systems to emulate natural processes or to incorporate new functions relies on a detailed understanding of the biochemical, mechanical, and other cues between cells and between cells and their environment that result in the coordinated action of multicellular systems. On April 3–6, 2022, experts in the field met at the Keystone symposium “Engineering Multicellular Living Systems” to discuss recent advances in understanding how cells cooperate within a multicellular system, as well as recent efforts to engineer systems like organ-on-a-chip models, biological robots, and organoids. Given the similarities and common themes, this meeting was held in conjunction with the symposium “Organoids as Tools for Fundamental Discovery and Translation”.
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影响因子：
48
作者：
Chen F;Wassie AT;Cote AJ;Sinha A;Alon S;Asano S;Daugharthy ER;Chang JB;Marblestone A;Church GM;Raj A;Boyden ES
通讯作者：
Boyden ES
影响因子：
4.6
作者：
Chan V;Park K;Collens MB;Kong H;Saif TA;Bashir R
通讯作者：
Bashir R
影响因子：
13.6
作者：
Hinton TJ;Jallerat Q;Palchesko RN;Park JH;Grodzicki MS;Shue HJ;Ramadan MH;Hudson AR;Feinberg AW
通讯作者：
Feinberg AW
影响因子：
14.8
作者：
Campostrini G;Meraviglia V;Giacomelli E;van Helden RWJ;Yiangou L;Davis RP;Bellin M;Orlova VV;Mummery CL
通讯作者：
Mummery CL
影响因子：
6.1
作者：
Grosberg A;Alford PW;McCain ML;Parker KK
通讯作者：
Parker KK