CXCL10 decreases GP73 expression in hepatoma cells at the early stage of hepatitis C virus (HCV) infection.
CXCL10 decreases GP73 expression in hepatoma cells at the early stage of hepatitis C virus (HCV) infection.
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CXCL10 在丙型肝炎病毒 (HCV) 感染早期降低肝癌细胞中 GP73 的表达。
DOI：
10.3390/ijms141224230
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发表时间：
2013-12-13
影响因子：
5.6
通讯作者：
Zeng P
中科院分区：
文献类型：
--
作者：
Liu Y;Zou Z;Zhu B;Hu Z;Zeng P
高尔基蛋白73 （GP73）在肝细胞癌（HCC）中上调，最近被确定为HCC诊断的一种新的血清标志物。几份报告还指出，GP73在各种病因的急性肝炎、慢性丙型肝炎病毒（HCV）感染和酒精性肝病患者的慢性肝病中表达水平升高。GP73在HCV相关肝病中的表达的分子机制仍有待明确。在本研究中，我们旨在评估HCV感染对GP73表达的影响。GP73在Huh7、Hep3B、293T和HUVEC细胞中高表达，在HepG2细胞中低表达。HCV感染导致Huh7和HepG2/CD81细胞在感染早期下调GP73表达。CXCL10降低了Huh7和HepG2细胞中GP73的表达。在HCV感染晚期，GP73在肝细胞中表达上调，具有细胞病变作用，影响GP73表达的未知因素有待进一步研究。总之，我们的研究为GP73在肝脏疾病中的作用提供了额外的证据。
Golgi protein 73 (GP73), which is up-regulated in hepatocellular carcinoma (HCC), has recently been identified as a novel serum marker for HCC diagnosis. Several reports also noted the increased levels of GP73 expression in chronic liver disease in patients with acute hepatitis of various etiologies, chronic Hepatitis C virus (HCV) infection and alcoholic liver disease. The molecular mechanisms of GP73 expression in HCV related liver disease still need to be determined. In this study, we aimed to evaluate the effect of HCV infection on GP73 expression. GP73 was highly expressed in Huh7, Hep3B, 293T and HUVEC cells, and was low-expressed in HepG2 cells. HCV infection led to down-regulation of GP73 in Huh7 and HepG2/CD81 cells at the early stage of infection. CXCL10 decreased GP73 expression in Huh7 and HepG2 cells. Up-regulation of GP73 was noted in hepatocytes with cytopathic effect at advanced stage of HCV infection, and further research is needed to determine the unknown factors affecting GP73 expression. In conclusion, our study provided additional evidence for the roles of GP73 in liver disease.
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DOI：
10.3233/cbm-2012-00276
发表时间：
2012
期刊：
Cancer biomarkers : section A of Disease markers
影响因子：
--
作者：
Liang H;Block TM;Wang M;Nefsky B;Long R;Hafner J;Mehta AS;Marrero J;Gish R;Norton PA
通讯作者：
Norton PA
影响因子：
3.7
作者：
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Chau, Gar-Yang
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影响因子：
2.8
作者：
Zhang, Fangfang;Gu, Yanli;Peng, Tao
通讯作者：
Peng, Tao
影响因子：
3.7
作者：
Wei H;Li B;Zhang R;Hao X;Huang Y;Qiao Y;Hou J;Li X;Li X
通讯作者：
Li X
DOI：
10.1016/j.bbadis.2006.06.017
发表时间：
2006-09-01
影响因子：
6.2
作者：
Nagpal, Madan L.;Davis, Jeffrey;Lin, Tu
通讯作者：
Lin, Tu