Mechanical properties of meniscal circumferential fibers using an inverse finite element analysis approach.
Mechanical properties of meniscal circumferential fibers using an inverse finite element analysis approach.
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DOI：
10.1016/j.jmbbm.2022.105073
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发表时间：
2022-03
影响因子：
3.9
通讯作者：
Travascio, Francesco
中科院分区：
文献类型：
--
作者：
De Rosa, Massimiliano;Filippone, Giovanni;Best, Thomas M.;Jackson, Alicia R.;Travascio, Francesco
关键词：
半月板的细胞外基质（ECM）是包埋主要沿周向定向的胶原纤维束的蛋白聚糖的凝胶样水溶液。胶原纤维对生物力学有重要贡献，但对其力学性能知之甚少。本研究的目的是提出一个本构模型的胶原纤维嵌入ECM的半月板和表征组织的相关机械性能。假设线性纤维增强粘弹性本构模型适合描述剪切下的粘弹性力学行为。进一步假设，控制模型的机械性能取决于组织的组成。对8个猪尿道标本进行了扫频试验。第一组实验数据来自组织样本，其中使用相对于剪切平面平行取向的胶原纤维。这样做是为了消除胶原纤维对机械响应的贡献，并表征ECM的机械性能。第二组具有相对于剪切平面正交取向的纤维，其用于通过逆有限元分析确定胶原纤维的弹性特性。我们的测试方案表明，组织ECM机械行为可以通过具有3个驰豫时间的广义麦克斯韦模型来描述。逆有限元分析表明，胶原纤维可以被建模为具有平均弹性模量为287.5± 62.6MPa的线弹性元件。ECM和纤维的力学参数的大小与组织含水量呈负相关。
The extracellular matrix (ECM) of the meniscus is a gel-like water solution of proteoglycans embedding bundles of collagen fibers mainly oriented circumferentially. Collagen fibers significantly contribute to meniscal mechanics, however little is known about their mechanical properties. The objective of this study was to propose a constitutive model for collagen fibers embedded in the ECM of the meniscus and to characterize the tissue’s pertinent mechanical properties. It was hypothesized that a linear fiber reinforced viscoelastic constitutive model is suitable to describe meniscal mechanical behavior in shear. It was further hypothesized that the mechanical properties governing the model depend on the tissue’s composition. Frequency sweep tests were conducted on eight porcine meniscal specimens. A first cohort of experimental data resulted from tissue specimens where collagen fibers oriented parallel with respect to the shear plane were used. This was done to eliminate the contribution of collagen fibers from the mechanical response and characterize the mechanical properties of the ECM. A second cohort with fibers orthogonally oriented with respect to the shear plane that were used to determine the elastic properties of the collagen fibers via inverse finite element analysis. Our testing protocol revealed that tissue ECM mechanical behavior could be described by a generalized Maxwell model with 3 relaxation times. The inverse finite element analysis suggested that collagen fibers can be modeled as linear elastic elements having an average elastic modulus of 287.5±62.6 MPa. Magnitudes of the mechanical parameters governing the ECM and fibers were negatively related to tissue water content.
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影响因子：
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作者：
Kazemi M;Dabiri Y;Li LP
通讯作者：
Li LP
DOI：
10.1002/jbm.820290706
发表时间：
1995-07-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
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WOO, SLY
影响因子：
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作者：
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通讯作者：
GERSHUNI, DH
DOI：
10.2106/00004623-197658010-00016
发表时间：
1976-01-01
影响因子：
5.3
作者：
HSIEH, HH;WALKER, PS
通讯作者：
WALKER, PS
DOI：
10.1016/j.jmbbm.2019.02.020
发表时间：
2019-06-01
影响因子：
3.9
作者：
Murphy, Caroline A.;Cunniffe, Grainne M.;Collins, Maurice N.
通讯作者：
Collins, Maurice N.