Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo.
Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo.
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DOI：
10.4049/jimmunol.1102500
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发表时间：
2012-02-01
期刊：
影响因子：
--
通讯作者：
Tedder TF
中科院分区：
文献类型：
--
作者：
Maseda D;Smith SH;DiLillo DJ;Bryant JM;Candando KM;Weaver CT;Tedder TF
调节性B细胞在功能上由其表达IL-10的能力（B10细胞）来定义，其下调炎症和自身免疫。在使用定义明确的IL-10报告小鼠的研究中，还发现这种罕见的B10细胞亚群保持浆细胞分化的能力。在IL-10转录的短暂期间，B10细胞中的blimp-1和irf4转录因子被诱导，而pax-5和bcl-6被下调，因为B10细胞的显著部分完成了导致体外和体内抗体分泌细胞分化的遗传和表型程序。B10细胞来源的IgM与自身和外来的Ag反应，而B10细胞产生Ag特异性IgG响应于免疫。此外，B10细胞在过继转移实验中代表了血清IgM和IgG的重要来源，并产生了Ag特异性、多反应性和自身反应性抗体特异性，这些特异性与其表达的不同Ag受体库一致。因此，B10细胞不仅通过瞬时产生IL-10来限制炎症和免疫应答，而且还可以通过在体液免疫应答期间快速产生多反应性和/或Ag特异性抗体的固有能力来促进其引发的Ag的清除。
Regulatory B cells that are functionally defined by their capacity to express IL-10 (B10 cells) downregulate inflammation and autoimmunity. In studies using well-defined IL-10-reporter mice, this rare B10 cell subset was also found to maintain a capacity for plasma cell differentiation. During a transient period of il10 transcription, the blimp1 and irf4 transcription factors were induced in B10 cells while pax5 and bcl6 were downregulated as a significant fraction of B10 cells completed the genetic and phenotypic program leading to antibody-secreting cell differentiation in vitro and in vivo. B10 cell-derived IgM reacted with both self and foreign Ags, whereas B10 cells generated Ag-specific IgG in response to immunizations. Moreover, B10 cells represented a significant source of serum IgM and IgG during adoptive transfer experiments, and produced Ag-specific, polyreactive and autoreactive antibody specificities that were consistent with their expression of a diverse Ag receptor repertoire. Thereby, B10 cells not only limit inflammation and immune responses by the transient production of IL-10, but may also facilitate clearance of their eliciting Ags through an inherent capacity to quickly generate polyreactive and/or Ag-specific antibodies during humoral immune responses.
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影响因子：
15.9
作者：
Matsushita, Takashi;Yanaba, Koichi;Tedder, Thomas F.
通讯作者：
Tedder, Thomas F.
影响因子：
32.4
作者：
Kamanaka, Masahito;Kim, Sean T.;Flavell, Richard A.
通讯作者：
Flavell, Richard A.
影响因子：
30.5
作者：
Cretney, Erika;Xin, Annie;Kallies, Axel
通讯作者：
Kallies, Axel
DOI：
10.1084/jem.179.2.757
发表时间：
1994-02-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Brière F;Servet-Delprat C;Bridon JM;Saint-Remy JM;Banchereau J
通讯作者：
Banchereau J
影响因子：
--
作者：
Jiang, Chuancang;Zhao, Ming-Lang;Scearce, Richard M.;Diaz, Marilyn
通讯作者：
Diaz, Marilyn