Intravenous ethanol infusion decreases human cortical γ-aminobutyric acid and N-acetylaspartate as measured with proton magnetic resonance spectroscopy at 4 tesla.
Intravenous ethanol infusion decreases human cortical γ-aminobutyric acid and N-acetylaspartate as measured with proton magnetic resonance spectroscopy at 4 tesla.
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DOI：
10.1016/j.biopsych.2011.06.026
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发表时间：
2012-02-01
影响因子：
10.6
通讯作者：
Mason, Graeme F.
中科院分区：
文献类型：
--
作者：
Gomez, Rosane;Behar, Kevin L.;Watzl, June;Weinzimer, Stuart A.;Gulanski, Barbara;Sanacora, Gerard;Koretski, Julia;Guidone, Elizabeth;Jiang, Lihong;Petrakis, Ismene L.;Pittman, Brian;Krystal, John H.;Mason, Graeme F.
乙醇调节谷氨酸和GABA的功能。然而，很少有人知道乙醇对GABA，谷氨酸和其他代谢产物的水平的急性药理学作用，在人体皮质在体内使用1H磁共振波谱（MRS）测量。11名健康的社交饮酒者接受了两次静脉注射乙醇，在60-70分钟内将呼吸酒精水平提高到60 mg/dL的固定平台。第一次输注确定了该程序的耐受性，第二次程序在15±12天后进行，在枕叶GABA、谷氨酸和其他代谢产物的1H MRS期间进行。脑乙醇的时间过程接近呼吸乙醇，但静脉乙醇滞后约7分钟。乙醇输注5分钟后，GABA下降13±8%，并在整个测量过程中保持降低（p=0.003）。在输注期间，N-乙酰天冬氨酸和N-乙酰谷氨酸酯的组合（总和为NAA）稳定下降8±3%（p=0.0036）。乙醇降低了人类大脑皮层GABA和NAA的水平。GABA水平的降低与乙醇促进GABAA受体功能一致。NAA水平的逐渐下降表明大脑中的神经或代谢活动受到抑制。
Ethanol modulates glutamate and GABA function. However, little is known about the acute pharmacologic effects of ethanol on levels of GABA, glutamate, and other metabolites measurable in the human cortex in vivo using 1H magnetic resonance spectroscopy (MRS). Eleven healthy social drinkers received two intravenous ethanol infusions that raised breath alcohol levels to a clamped plateau of 60 mg/dL over 60–70 minutes. The first infusion established tolerability of the procedure, and the second procedure, conducted 15±12 days later, was performed during 1H MRS of occipital GABA, glutamate, and other metabolites. The time course of brain ethanol approximated that of breath ethanol, but venous ethanol lagged by about 7 minutes. GABA fell 13±8% after 5 minutes of the ethanol infusion and remained reduced (p=0.003) throughout the measurement. The combination of N-acetylaspartate and N-acetylaspartyl glutamate (summed as NAA) fell steadily during the infusion by 8±3% (p=0.0036). Ethanol reduced cortical GABA and NAA levels in humans. Reductions in GABA levels are consistent with facilitation of GABAA receptor function by ethanol. The gradual decline in NAA levels suggests inhibition of neural or metabolic activity in the brain.
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影响因子：
7.6
作者：
Adalsteinsson, Elfar;Sullivan, Edith V.;Pfefferbaum, Adolf
通讯作者：
Pfefferbaum, Adolf
影响因子：
6.3
作者：
Biller, Armin;Bartsch, Andreas J.;Bendszus, Martin
通讯作者：
Bendszus, Martin
DOI：
10.1111/j.1530-0277.1998.tb03611.x
发表时间：
1998-02-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Koob, GF;Roberts, AJ;Weiss, F
通讯作者：
Weiss, F
影响因子：
5.7
作者：
Ende, Gabriele;Walter, Sigi;Mann, Karl
通讯作者：
Mann, Karl
DOI：
10.1097/01.alc.0000150010.72739.58
发表时间：
2005-01-01
影响因子：
3.2
作者：
Mason, GF;Bendszus, M;Krystal, JH
通讯作者：
Krystal, JH