Magnetometric evaluation of the effects of gallium arsenide on the clearance and relaxation of iron particles.
Magnetometric evaluation of the effects of gallium arsenide on the clearance and relaxation of iron particles.
复制标题
磁力法评估砷化镓对铁颗粒清除和松弛的影响。
作者：
Y. Aizawa;T. Takata;H. Karube;H. Tatsumi;Natsuko Inokuchi;M. Kotani;K. Chiyotani
组织病理学显示，肺内滴注GaAs混悬液可诱导弥漫性肺反应。本研究采用磁法研究了家兔肺内注入GaAs对注入外源性磁化铁颗粒的影响。磁测量评估的影响，砷化镓在兔剂量为30毫克或300毫克/动物显示显着减少铁颗粒的松弛后1，3，7，14，21和28天滴注与对照组相比。弛豫表明，由于巨噬细胞中吞噬的铁颗粒的随机旋转，在肺部磁化后，磁共振磁场迅速降低。铁颗粒的清除率通过在磁化结束时从弛豫曲线估计的弛豫磁场的连续测定来测量。在滴注后14、21和28天，暴露于两种剂量GaAs的兔的清除率显著受损。在两种情况下均观察到剂量-效应关系。用这些剂量滴注的肺的组织学检查表明肺泡巨噬细胞对GaAs和铁颗粒的主动吞噬作用。
Intratracheal instillation of GaAs suspension has been histopathologically shown to induce a diffuse pulmonary response. In the present study, magnetometry was used to evaluate the effects of intratracheally instilled GaAs on the behavior of externally magnetized iron particles instilled in rabbit lung. Magnetometric evaluation of the effects of GaAs in rabbits dosed with 30 mg or 300 mg/animal showed significant decreased relaxation of iron particles at 1, 3, 7, 14, 21 and 28 days following instillation compared with the controls. Relaxation indicates a rapid decrease of remanent magnetic field following magnetization of the lungs due to random rotation of phagocytized iron particles in macrophages. Clearance of the iron particles was measured by serial determinations of the remanent magnetic field at the end of magnetization estimated from relaxation curves. Clearance was significantly impaired in rabbits exposed to both doses of GaAs at 14, 21 and 28 days after instillation. Dose-effect relationships were observed in both cases. Histological examination of lungs instilled with these doses indicated active phagocytosis of GaAs and iron particles by alveolar macrophages.
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影响因子：
3.8
作者：
SIKORSKI, EE;BURNS, LA;MUNSON, AE
通讯作者：
MUNSON, AE
气管内滴注砷化镓、氧化镓(III)或氧化砷(III)给大鼠的肺毒性比较。
影响因子：
3.8
作者：
Webb,DR;Wilson,SE;Carter,DE
通讯作者：
Carter,DE
暴露于砷化镓的小鼠脾脏辅助细胞功能的抑制。
影响因子：
3.8
作者：
Sikorski,EE;Burns,LA;McCoy,KL;Stern,M;Munson,AE
通讯作者：
Munson,AE
大鼠气管内滴注可吸入砷化镓颗粒的肺清除率和毒性。
DOI：
10.1080/15298668791385372
发表时间：
1987
期刊：
American Industrial Hygiene Association journal
影响因子：
--
作者：
Webb,DR;Wilson,SE;Carter,DE
通讯作者：
Carter,DE
砷化镓的体外溶解度和体内毒性。
影响因子：
3.8
作者：
Webb,DR;Sipes,IG;Carter,DE
通讯作者：
Carter,DE