Neuroimaging of vascular reserve in patients with cerebrovascular diseases.
Neuroimaging of vascular reserve in patients with cerebrovascular diseases.
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DOI:
10.1016/j.neuroimage.2017.10.015
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发表时间:
2019-02-15
期刊:
影响因子:
5.7
通讯作者:
Donahue MJ
中科院分区:
文献类型:
--
作者:
Juttukonda MR;Donahue MJ
Cerebrovascular reactivity, defined broadly as the ability of brain parenchyma to adjust cerebral blood flow in response to altered metabolic demand or a vasoactive stimulus, is being measured with increasing frequency and may have a use for portending new or recurrent stroke risk in patients with cerebrovascular disease. The purpose of this review is to outline (i) the physiological basis of variations in cerebrovascular reactivity, (ii) available approaches for measuring cerebrovascular reactivity in research and clinical settings, and (iii) clinically-relevant cerebrovascular reactivity findings in the context of patients with cerebrovascular disease, including atherosclerotic arterial steno-occlusion, non-atherosclerotic arterial steno-occlusion, anemia, and aging. Literature references summarizing safety considerations for these procedures and future directions for standardizing protocols and post-processing procedures across centers are presented in the specific context of major unmet needs in the setting of cerebrovascular disease.
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