The Potential Role of Exosomal Proteins in Prostate Cancer.
The Potential Role of Exosomal Proteins in Prostate Cancer.
复制标题
外泌体蛋白在前列腺癌中的潜在作用
DOI：
10.3389/fonc.2022.873296
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发表时间：
2022
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
前列腺癌是发达国家男性中最常见的恶性肿瘤。这种肿瘤的传统诊断和治疗方法越来越难以适应当今的医学理念，从而影响了早期检测，诊断和治疗。寻找新的诊断标志物和治疗靶点已成为当今研究的热点。值得注意的是，已经广泛研究了外泌体，其特征在于由细胞释放的磷脂双层结构的小囊泡，其能够递送靶向特定细胞以调节生物学特性的不同类型的货物。外泌体的组成，加上它们与细胞的相互作用，使它们成为癌症发展中的多方面调节剂。许多研究已经描述了前列腺癌来源的外泌体蛋白在前列腺癌的诊断和治疗中的作用。但到目前为止，还没有相关文献系统总结其在肿瘤中的作用，这给相关蛋白的后期研究带来了障碍。本文综述了前列腺癌中来源于不同来源的外泌体蛋白及其在肿瘤发生和耐药中的作用。
Prostate cancer is the most prevalent malignant tumor in men across developed countries. Traditional diagnostic and therapeutic methods for this tumor have become increasingly difficult to adapt to today’s medical philosophy, thus compromising early detection, diagnosis, and treatment. Prospecting for new diagnostic markers and therapeutic targets has become a hot topic in today’s research. Notably, exosomes, small vesicles characterized by a phospholipid bilayer structure released by cells that is capable of delivering different types of cargo that target specific cells to regulate biological properties, have been extensively studied. Exosomes composition, coupled with their interactions with cells make them multifaceted regulators in cancer development. Numerous studies have described the role of prostate cancer-derived exosomal proteins in diagnosis and treatment of prostate cancer. However, so far, there is no relevant literature to systematically summarize its role in tumors, which brings obstacles to the later research of related proteins. In this review, we summarize exosomal proteins derived from prostate cancer from different sources and summarize their roles in tumor development and drug resistance.
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