Expiratory flow rate, breath hold and anatomic dead space influence electronic nose ability to detect lung cancer.
Expiratory flow rate, breath hold and anatomic dead space influence electronic nose ability to detect lung cancer.
复制标题
DOI：
10.1186/1471-2466-14-202
复制
发表时间：
2014-12-16
影响因子：
3.1
通讯作者：
Horvath I
中科院分区：
文献类型：
--
作者：
Bikov A;Hernadi M;Korosi BZ;Kunos L;Zsamboki G;Sutto Z;Tarnoki AD;Tarnoki DL;Losonczy G;Horvath I
电子鼻是纳米传感器阵列的复合材料。大量研究表明，通过分析呼出的挥发性化合物模式（“呼吸指纹”），它们有可能从呼吸样本中检测肺癌。呼气流速、屏气和解剖死腔的存在可能影响某些挥发性化合物的呼出水平；然而，目前还没有完全解决这些因素如何影响电子鼻数据。因此，本研究的目的是调查这些影响。37例健康受试者（44±14岁）和27例肺癌患者（60±10岁）参与研究。通过挥发性有机化合物过滤器深度吸入后，受试者以两种不同的流速（50毫升/秒和75毫升/秒）将气体呼入特氟龙涂层袋。在深吸10秒后分析屏气的效果。我们还通过排除这部分并将肺泡空气与混合（肺泡+解剖死腔）空气样本进行比较，研究了解剖死腔的影响。呼出的空气样本用Cyranose 320电子鼻处理。在健康个体中，呼气流量、屏气和解剖死腔的包含显著改变了“呼吸指纹”（p < 0.05），但在肺癌中没有改变（p < 0.05）。这些因素也显著影响了电子鼻对肺癌的鉴别能力。我们用电子鼻评估了呼气流量、屏气和死腔对呼出挥发性化合物模式的影响。这些发现为电子鼻测量的样本采集标准化提供了重要的方法学建议。
Electronic noses are composites of nanosensor arrays. Numerous studies showed their potential to detect lung cancer from breath samples by analysing exhaled volatile compound pattern (“breathprint”). Expiratory flow rate, breath hold and inclusion of anatomic dead space may influence the exhaled levels of some volatile compounds; however it has not been fully addressed how these factors affect electronic nose data. Therefore, the aim of the study was to investigate these effects. 37 healthy subjects (44 ± 14 years) and 27 patients with lung cancer (60 ± 10 years) participated in the study. After deep inhalation through a volatile organic compound filter, subjects exhaled at two different flow rates (50 ml/sec and 75 ml/sec) into Teflon-coated bags. The effect of breath hold was analysed after 10 seconds of deep inhalation. We also studied the effect of anatomic dead space by excluding this fraction and comparing alveolar air to mixed (alveolar + anatomic dead space) air samples. Exhaled air samples were processed with Cyranose 320 electronic nose. Expiratory flow rate, breath hold and the inclusion of anatomic dead space significantly altered “breathprints” in healthy individuals (p < 0.05), but not in lung cancer (p > 0.05). These factors also influenced the discrimination ability of the electronic nose to detect lung cancer significantly. We have shown that expiratory flow, breath hold and dead space influence exhaled volatile compound pattern assessed with electronic nose. These findings suggest critical methodological recommendations to standardise sample collections for electronic nose measurements.
登录
查看更多内容
影响因子：
2.6
作者：
Bikov, Andras;Pako, Judit;Horvath, Ildiko
通讯作者：
Horvath, Ildiko
影响因子：
3.7
作者：
Bos LD;de Jong MD;Sterk PJ;Schultz MJ
通讯作者：
Schultz MJ
影响因子：
5.3
作者：
Dragonieri, Silvano;van der Schee, Marc P.;Sterk, Peter J.
通讯作者：
Sterk, Peter J.
影响因子：
3.8
作者：
Filipiak W;Ruzsanyi V;Mochalski P;Filipiak A;Bajtarevic A;Ager C;Denz H;Hilbe W;Jamnig H;Hackl M;Dzien A;Amann A
通讯作者：
Amann A
DOI：
10.1164/rccm.200906-0939oc
发表时间：
2009-12-01
影响因子：
24.7
作者：
Fens, Niki;Zwinderman, Aeilko H.;Sterk, Peter J.
通讯作者：
Sterk, Peter J.