Association of Brain Iron Overload With Brain Edema and Brain Atrophy After Intracerebral Hemorrhage.
Association of Brain Iron Overload With Brain Edema and Brain Atrophy After Intracerebral Hemorrhage.
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DOI：
10.3389/fneur.2020.602413
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发表时间：
2020
影响因子：
3.4
通讯作者：
Huang Y
中科院分区：
文献类型：
--
作者：
Liu R;Zhang H;Cheng S;Sun Y;Li H;Xiao J;Huang Y
目的：本研究使用 ESWAN 序列评估脑出血 (ICH) 后的铁过载。方法：这项单中心前瞻性观察队列研究纳入了幕上脑出血患者。在第 1 天、第 14 天、第 30 天和随访（300 天或更晚）时使用 3.0-T 扫描仪获得 MRI。 R2* 映射是基于 ESWAN 生成的。同侧R2*值代表铁沉积，对侧R2*值作为对照。 R2* 值根据容量进行调整，用于评估总铁超负荷。通过 T2 FLAIR 加权图像测量脑水肿。脑萎缩的计算方法为对侧半球体积减去受伤半球体积。结果：本次分析纳入了 27 名自发性幕上 ICH 患者。第 1 天、第 14 天和第 30 天的同侧 R2* 值分别为 40.27 ± 11.62、41.92 ± 13.56 和 60.89 ± 14.09。 ICH 侧的 R2* 值显着高于对侧 (p < 0.01)。与第 14 天相比，第 30 天的 R2* 值有所增加 (p < 0.01)。 R2* 值显示随着距血肿边缘距离的增加逻辑衰减 (p < 0.01)。第 14 天的脑水肿和随访时的脑萎缩与按第 14 天的体积调整的 R2* 值相关 (p < 0.01)。结论：ICH后第一个月内血肿周围区域的铁沉积逐渐增加。通过体积调整的R2*值预测急性脑水肿和慢性脑萎缩。
Objective: This study evaluated iron overload after intracerebral hemorrhage (ICH) using ESWAN sequences. Methods: This single-center prospective observational cohort study enrolled supratentorial ICH patients. MRI was obtained with a 3.0-T scanner at day 1, day 14, day 30, and follow-up (300 days or later). R2* mapping was generated based on the ESWAN. R2* value of the ipsilateral side represented iron deposition, and the R2* value of the contralateral side served as control. R2* value was adjusted by volume and used to assess total iron overload. Brain edema was measured on T2 FLAIR-weighted images. Brain atrophy was calculated as the contralateral hemisphere volume minus the injured hemisphere volume. Results: Twnety-seven patients with a spontaneous supratentorial ICH were included in this analysis. The ipsilateral R2* value was 40.27 ± 11.62, 41.92 ± 13.56, and 60.89 ± 14.09 at days 1, 14, and 30, respectively. The R2* value was significantly higher in the ICH side than the contralateral side (p < 0.01). Increased R2* value was seen on day 30 compared to day 14 (p < 0.01). The R2* value showed logistic decay with the distance to the hematoma margin (p < 0.01). Brain edema at day 14 and brain atrophy at follow-up correlated with R2* value adjusted by volume at day 14 (p < 0.01). Conclusions: After ICH, the iron deposition in the perihematomal region was progressively increased during the first month. R2* value adjusted by volume predicted acute brain edema and chronic brain atrophy.
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DOI：
10.1523/jneurosci.3252-09.2009
发表时间：
2009-12-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM
通讯作者：
Dale AM
影响因子：
8.3
作者：
Mehdiratta, Manu;Kumar, Sandeep;Selim, Magdy
通讯作者：
Selim, Magdy
影响因子：
8.3
作者：
Wu, JM;Hua, Y;Xi, GH
通讯作者：
Xi, GH
影响因子：
4.1
作者：
Nakamura, T;Keep, RF;Xi, GH
通讯作者：
Xi, GH
影响因子：
9.9
作者：
Knudsen, KA;Rosand, J;Greenberg, SM
通讯作者：
Greenberg, SM