Child maltreatment and gender interactions as predictors of differential neuroendocrine profiles.
Child maltreatment and gender interactions as predictors of differential neuroendocrine profiles.
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DOI：
10.1016/j.psyneuen.2012.12.019
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发表时间：
2013-08
影响因子：
3.7
通讯作者：
Dackis, Melissa N.
中科院分区：
文献类型：
--
作者：
Doom, Jenalee R.;Cicchetti, Dante;Rogosch, Fred A.;Dackis, Melissa N.
儿童虐待是一种与神经内分泌失调和终生精神和身体疾病风险增加相关的强有力的压力源。应激反应的性别差异和成人精神病理患病率可能与性别特异性应激反应有关。本研究的目的是研究性别是否与虐待压力相互作用，从而在儿童中产生不同的神经内分泌特征。参与者包括参加暑期研究日营的137名受虐待和110名未受虐待的低收入、不同种族和民族的儿童（范围：7.9-10.9岁；M= 9.42岁；52%为男性）。每天收集唾液3次，持续5天，用于皮质醇和脱氢表雄酮（DHEA）分析。检查了人类服务部门的记录，以确定虐待组中儿童的虐待类型、严重程度、慢性、发病和最近发生的情况。性别和虐待普遍性之间的显著相互作用预测了日皮质醇、脱氢表雄酮和皮质醇/脱氢表雄酮比值水平。据报道，在虐待更为普遍的一组中，男孩的每日皮质醇水平高于女孩。与有类似经历的女孩、未受虐待的男孩和受虐待更普遍的男孩相比，受虐待较少的男孩的DHEA水平较低，皮质醇/DHEA比值水平较高。进一步的结果表明，在遭受更普遍虐待的女孩和早期遭受虐待而不是最近的女孩中，皮质醇的分泌下调是一致的。对受虐待儿童的干预措施的有效性可能会随着对虐待如何根据性别差异影响神经内分泌调节的更多了解而得到改善。
Child maltreatment is a potent stressor associated with neuroendocrine dysregulation and increased risk for mental and physical disorders throughout the lifespan. Gender differences in stress reactivity and adult psychopathology prevalence may be related to sex-specific responsivity to stress. The purpose of this study is to examine whether gender interacts with the stress of maltreatment to produce differential neuroendocrine profiles in children. Participants included 137 maltreated and 110 nonmaltreated low-income, racially and ethnically diverse children (range: 7.9–10.9 years; M= 9.42 years; 52% male) who attended a summer research day camp. Saliva was collected 3 times across the day for 5 days for cortisol and dehydroepiandosterone (DHEA) analysis. Department of Human Services records were examined to determine the type, severity, chronicity, onset, and recency of maltreatment for children in the maltreated group. Significant interactions between gender and maltreatment pervasiveness predicted diurnal cortisol, DHEA, and cortisol/DHEA ratio levels. Elevated daily cortisol levels were reported for boys compared to girls in the group with more pervasive maltreatment. Boys with less pervasive maltreatment had lower DHEA and higher cortisol/DHEA ratio levels than girls with similar experiences, nonmaltreated boys, and boys with more pervasive maltreatment. Further results are consistent with down-regulation of cortisol production in girls with more pervasive maltreatment and girls who experienced maltreatment that was early onset and not recent. The effectiveness of interventions for maltreated children may be improved with greater knowledge of how maltreatment differentially affects neuroendocrine regulation by gender.
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