The Key Role of TNF-TNFR2 Interactions in the Modulation of Allergic Inflammation: A Review.
The Key Role of TNF-TNFR2 Interactions in the Modulation of Allergic Inflammation: A Review.
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DOI：
10.3389/fimmu.2018.02572
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发表时间：
2018
影响因子：
7.3
通讯作者：
Mohamud R
中科院分区：
文献类型：
--
作者：
Ahmad S;Azid NA;Boer JC;Lim J;Chen X;Plebanski M;Mohamud R
Tumor necrosis factor-alpha (TNF) is a pleiotropic cytokine, which is thought to play a major role in the pathogenesis of inflammatory diseases, including allergy. TNF is produced at the early stage of allergen sensitization, and then continues to promote the inflammation cascade in the effector phase of allergic reactions. Consequently, anti-TNF treatment has been proposed as a potential therapeutic option. However, recent studies reveal anti-intuitive effects of TNF in the activation and proliferative expansion of immunosuppressive Tregs, tolerogenic DCs and MDSCs. This immunosuppressive effect of TNF is mediated by TNFR2, which is preferentially expressed by immunosuppressive cells. These findings redefine the role of TNF in allergic reaction, and suggest that targeting TNF-TNFR2 interaction itself may represent a novel strategy in the treatment of allergy.
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影响因子：
5.4
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.1410579111
发表时间：
2014-08-12
影响因子：
11.1
作者：
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通讯作者：
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TNF受体2和疾病：自身免疫性和再生医学。
影响因子：
7.3
作者：
Faustman DL;Davis M
通讯作者：
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