Noncontact tissue ablation by Holmium: YSGG laser pulses in blood
Noncontact tissue ablation by Holmium: YSGG laser pulses in blood
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钬非接触式组织消融：血液中的 YSGG 激光脉冲
DOI：
10.1002/lsm.1900110108
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发表时间：
1991
影响因子：
2.4
通讯作者：
C. Borst
中科院分区：
文献类型：
--
作者：
T. V. van Leeuwen;M. J. van der Veen;R. Verdaasdonk;C. Borst
为了评估2.1 μm钬激光脉冲在非接触模式下动脉内组织消融的可行性，测量了激光脉冲在生理盐水和血液中的透射率。利用时间分辨闪光灯摄影技术研究了500 μs激光脉冲与光纤尖端盐水的时间相互作用。纤维在血液和生理盐水中的渗透深度取决于纤维输出的能量。在37°C的血液中，当脉冲强度分别为3.1至12.4 J/mm2时，穿透深度在1.2至2.1 mm之间变化，而其在水中的理论值为0.33 mm，这是基于测量的吸收系数3.0±0.1/mm。大穿透深度是由于光纤尖端周围形成了一个透明的蒸汽腔。生理盐水中，其最大长度为4.7 mm。其最大宽度为2.8 mm。空腔的寿命为450 μs。在血液中，可以在3mm的距离内消融猪主动脉。在邻近组织中观察到的大裂缝可能是由蒸汽腔的膨胀引起的。我们的结论是，由于“微秒区域的摩西效应”，Holmium: YSGG可以通过至少2.7毫米的血液进行组织消融。
To assess the feasibility of intra‐arterial tissue ablation by Holmium:YSGG laser pulses (2.1 μm) in a noncontact mode, the transmission of the laser pulses through saline and blood was measured. The temporal interaction between the 500 μs laser pulse and saline at the fiber tip was investigated with time‐resolved flash photography. The penetration depth in blood and saline depended on the fiber output energy. In blood at 37°C, the penetration depth varied from 1.2 to 2.1 mm for intensities of 3.1 to 12.4 J/mm2 per pulse, respectively, whereas its theoretical value for water is 0.33 mm, which is based on the measured absorption coefficient of 3.0 ± 0.1/mm. The large penetration depth was due to the development of a transparent vapour cavity around the fiber tip. In saline, its maximum length was 4.7 mm. Its maximum width was 2.8 mm. The lifetime of the cavity was 450 μs. In blood, ablation of porcine aorta was feasible at a distance of 3 mm. Large fissures observed in adjacent tissue are likely to be caused by the expansion of the vapour cavity. We conclude that, due to a “Moses effect in the microsecond region,” Holmium: YSGG tissue ablation is possible through at least 2.7 mm of blood.
DOI：
10.1016/s0735-1097(85)80435-6
发表时间：
1985-01-01
影响因子：
24
作者：
GRUNDFEST, WS;LITVACK, F;LAUDENSLAGER, JB
通讯作者：
LAUDENSLAGER, JB
经皮准分子激光和准分子激光辅助下肢血管成形术：初步临床试验的结果。
影响因子：
19.7
作者：
Litvack,F;Grundfest,WS;Adler,L;Hickey,AE;Segalowitz,J;Hestrin,LB;Mohr,FW;Goldenberg,T;Laudenslager,JS;Forrester,JS
通讯作者：
Forrester,JS