Ginseng compounds: an update on their molecular mechanisms and medical applications.
Ginseng compounds: an update on their molecular mechanisms and medical applications.
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DOI：
10.2174/157016109788340767
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发表时间：
2009-07
影响因子：
4.5
通讯作者：
Chen C
中科院分区：
文献类型：
--
作者：
Lü JM;Yao Q;Chen C
人参是应用最广泛的中草药之一，据报道具有广泛的治疗和药理作用。人参皂苷是人参的主要药理活性成分，似乎与人参的大部分活性有关，包括血管松弛、抗氧化、抗炎和抗癌。目前已鉴定出约40种人参皂苷化合物。研究人员目前的研究重点是用纯化的单株人参皂苷来揭示人参的具体作用机制，而不是使用完整的人参根提取物。不同的人参皂苷由于其化学结构不同，可能具有不同的药理作用和机制。其中研究最多的是人参皂苷Rb1、Rg1、Rg3、Re、Rd和Rh1。人参皂苷的分子机制及其在医学上的应用引起了人们的广泛关注，在过去的几年里已经发表了数百篇论文。这一更新的总体目的是提供最近描述的人参皂苷在抗氧化、血管系统、信号转导通路以及与受体相互作用方面的最新信息。本文还讨论了人参皂苷在动物模型和人体中的治疗应用，以及人参皂苷的药代动力学和毒性。本文最后对人参类化合物作为有效治疗剂的进一步开发提出了一些思考。
Ginseng is one of the most widely used herbal medicines and is reported to have a wide range of therapeutic and pharmacological applications. Ginsenosides, the major pharmacologically active ingredients of ginseng, appear to be responsible for most of the activities of ginseng including vasorelaxation, antioxidation, anti-inflammation and anti-cancer. Approximately 40 ginsenoside compounds have been identified. Researchers are now focused on using purified individual ginsenoside to reveal the specific mechanism of functions of ginseng instead of using whole ginseng root extracts. Each ginsenoside may have different effects in pharmacology and mechanisms due to their different chemical structures. Among them the most commonly studied ginsenosides are Rb1, Rg1, Rg3, Re, Rd and Rh1. The molecular mechanisms and medical applications of ginsenosides have attracted much attention and hundreds of papers have been published in the last few years. The general purpose of this update is to provide current information on recently described effects of ginsenosides on antioxidation, vascular system, signal transduction pathways and interaction with receptors. Their therapeutic applications in animal models and humans as well as the pharmacokinetics and toxicity of ginsenosides are also discussed in this review. This review concludes with some thoughts for future directions in the further development of ginseng compounds as effective therapeutic agents.
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影响因子：
4.8
作者：
Chen, Feng;Eckman, Elizabeth A.;Eckman, Christopher B.
通讯作者：
Eckman, Christopher B.
影响因子：
2.5
作者：
Choi, Kyungsun;Kim, Myungsun;Choi, Chulhee
通讯作者：
Choi, Chulhee
影响因子：
6.2
作者：
Cai, ZW;Qian, TX;Jiang, ZH
通讯作者：
Jiang, ZH
影响因子：
2.5
作者：
Fujita, Kensuke;Hakuba, Nobuhiro;Gyo, Kiyofumi
通讯作者：
Gyo, Kiyofumi
DOI：
10.1016/s0378-4347(96)00304-0
发表时间：
1997-02-21
影响因子：
3
作者：
Cui, JF;Bjorkhem, I;Eneroth, P
通讯作者：
Eneroth, P