Behavioural assays to model cognitive and affective dimensions of depression and anxiety in rats.
Behavioural assays to model cognitive and affective dimensions of depression and anxiety in rats.
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DOI：
10.1111/j.1365-2826.2008.01772.x
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发表时间：
2008-10
影响因子：
3.2
通讯作者：
Morilak DA
中科院分区：
文献类型：
--
作者：
Lapiz-Bluhm MD;Bondi CO;Doyen J;Rodriguez GA;Bédard-Arana T;Morilak DA
动物模型已被广泛用于研究神经精神疾病，如抑郁症及其治疗。然而，许多此类疾病的病因和病理生理学在很大程度上是未知的，这使得动物模型的验证特别具有挑战性。此外，许多诊断症状很难定义、操作和量化，特别是在大鼠等实验动物身上。因此，与其试图对像抑郁症这样的复杂人类症状进行整体建模，不如更有成效地定义和建模疾病的组成部分，这些组成部分可能会解释一系列共同的不同症状，并可能共享共同的潜在神经生物学机制。在我们对应激与抑郁和焦虑障碍之间的神经调节机制以及抗抑郁药物慢性治疗在这些情况下发挥有益作用的机制的临床前研究中，我们使用了一些大鼠的行为测试来模拟抑郁和焦虑障碍的特定认知和焦虑样成分。在本文中，我们回顾了四种这样的行为测试：注意定势转移测试、高架迷宫测试、社会互动测试和电击探头防御掩埋测试。其目的是作为这些工具的实用性和局限性的指南，并帮助优化其使用和生产力。
Animal models have been used extensively to investigate neuropsychiatric disorders, such as depression, and their treatment. However, the etiology and pathophysiology of many such disorders are largely unknown, which makes validation of animal models particularly challenging. Further, many diagnostic symptoms are difficult to define, operationalize and quantify, especially in experimental animals such as rats. Thus, rather than attempting to model such complex human syndromes as depression in their entirety, it can be more productive instead to define and model components of the illness that may account for clusters of co-varying symptoms, and that may share common underlying neurobiological mechanisms. In our preclinical investigations of the neural regulatory mechanisms linking stress to depression and anxiety disorders, as well as the mechanisms by which chronic treatment with antidepressant drugs may exert their beneficial effects in these conditions, we have employed a number of behavioral tests in rats to model specific cognitive and anxiety-like components of depression and anxiety disorders. In this paper, we review the procedures for conducting four such behavioral assays: the attentional set-shifting test, the elevated-plus maze, the social interaction test and the shock-probe defensive burying test. The purpose is to serve as a guide to the utility and limitations of these tools, and as an aid in optimizing their use and productivity.
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影响因子：
2.6
作者：
Brudzynski, SM
通讯作者：
Brudzynski, SM
影响因子：
3.4
作者：
Basso, AM;Spina, M;Koob, GF
通讯作者：
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作者：
BALDWIN, HA;FILE, SE
通讯作者：
FILE, SE
影响因子：
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作者：
Cecchi, M;Khoshbouei, H;Morilak, DA
通讯作者：
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影响因子：
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作者：
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通讯作者：
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