Impact of PINCH expression on survival in colorectal cancer patients.
Impact of PINCH expression on survival in colorectal cancer patients.
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DOI：
10.1186/1471-2407-11-103
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发表时间：
2011-03-22
期刊：
影响因子：
3.8
通讯作者：
Sun XF
中科院分区：
文献类型：
--
作者：
Lööf J;Rosell J;Bratthäll C;Doré S;Starkhammar H;Zhang H;Sun XF
接头蛋白PINCH在几种类型的癌症的间质中高表达，是结直肠癌的独立预后标志物。在这项研究中，我们进一步研究了PINCH与结直肠癌化疗反应之间的关系。采用免疫组织化学方法，对251例原发腺癌、149例癌旁正常粘膜、57例远端正常粘膜和75例淋巴结转移癌石蜡包埋组织切片进行免疫组织化学染色。从正常粘膜到原发肿瘤再到转移，间质中PINCH的染色逐渐增强。癌旁正常粘膜的强阳性表达与患者的性别、年龄、肿瘤部位、分化程度和分期无关(p=0.044，HR，1.6 0，95%CI，1.0 1~2.5 2)。侵袭性边缘的夹点染色倾向于与生存相关(p=0.051)。在分化较低的肿瘤中，侵袭边缘的夹点染色与生存无关(p=0.013，HR，1.9，95%CI，1.14-3.16)，而在分化较好的肿瘤中，与生存无关。在染色较弱的患者中，辅助化疗与生存期有关(在整个肿瘤区域、浸润性切缘和肿瘤内部区域，p分别为0.010、0.013和0.013)，而在染色较强的患者中，辅助化疗与患者的生存无关。然而，在多变量分析中，没有发现这种关系。正常癌旁粘膜的PINCH染色与患者的生存有关。此外，肿瘤侵袭边缘的PINCH染色与低分化肿瘤的存活率有关，但与分化较好的肿瘤无关，表明PINCH对预后的影响取决于分化状况。
The adaptor protein PINCH is overexpressed in the stroma of several types of cancer, and is an independent prognostic marker in colorectal cancer. In this study we further investigate the relationship of PINCH and survival regarding the response to chemotherapy in colorectal cancer. Paraffin-embedded tissue sections from 251 primary adenocarcinomas, 149 samples of adjacent normal mucosa, 57 samples of distant normal mucosa and 75 lymph node metastases were used for immunohistochemical staining. Stromal staining for PINCH increased from normal mucosa to primary tumour to metastasis. Strong staining in adjacent normal mucosa was related to worse survival independently of sex, age, tumour location, differentiation and stage (p = 0.044, HR, 1.60, 95% CI, 1.01-2.52). PINCH staining at the invasive margin tended to be related to survival (p = 0.051). In poorly differentiated tumours PINCH staining at the invasive margin was related to survival independently of sex, age and stage (p = 0.013, HR, 1.90, 95% CI, 1.14-3.16), while in better differentiated tumours it was not. In patients with weak staining, adjuvant chemotherapy was related to survival (p = 0.010, 0.013 and 0.013 in entire tumour area, invasive margin and inner tumour area, respectively), but not in patients with strong staining. However, in the multivariate analysis no such relationship was seen. PINCH staining in normal adjacent mucosa was related to survival. Further, PINCH staining at the tumour invasive margin was related to survival in poorly differentiated tumours but not in better differentiated tumours, indicating that the impact of PINCH on prognosis was dependent on differentiation status.
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影响因子：
8.4
作者：
Ioachim, E;Charchanti, A;Pavlidis, N
通讯作者：
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影响因子：
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影响因子：
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作者：
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影响因子：
4.8
作者：
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通讯作者：
Sun, XF