Second primary malignancy among malignant solid tumor survivors aged 85 years and older.
Second primary malignancy among malignant solid tumor survivors aged 85 years and older.
复制标题
85 岁及以上恶性实体瘤幸存者中的第二原发恶性肿瘤
DOI：
10.1038/s41598-021-99260-6
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发表时间：
2021-10-05
影响因子：
4.6
通讯作者：
Yang Q
中科院分区：
文献类型：
--
作者：
Zhang Z;Liu F;Qu Y;Qiu L;Zhang L;Yang Q
The cancer burden in the oldest old has increased rapidly. This study aimed to investigate the epidemiology of second primary malignancy (SPM) in malignant solid tumor survivors aged 85 years and older utilizing the Surveillance, Epidemiology, and End Results (SEER) database. A total of 128,466 malignant solid tumor patients had been identified between 2000 and 2011, including 6774 patients who developed a SPM. The overall crude incidence of developing a SPM was 5.3%. Considering death as a competing event, the 3, 5, and 10-year cumulative incidence was 1.9%, 3.2%, and 5.4%, respectively. Relative younger age, male gender, surgery history, local stage and first primary malignancy (FPM) site located in the urinary system were related to higher cumulative incidence. A median time interval of 24.0 months was found between diagnosis of FPM and SPM. The most common SPM site was digestive system, whereas the least common was oral cavity and pharynx. The median overall survival (OS) was 49.0 months, and the median survival after SPM was 13.0 months. Relative older age, male gender and black race were associated with worse OS and survival after SPM, as well as higher hazard ratios of death. In conclusions, this study performed a comprehensive analysis of SPM among malignant solid tumor survivors aged 85 years and older. Additional studies are needed to characterize the specific cancer type of interest.
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影响因子：
5
作者：
Tanskanen T;Seppä KJM;Virtanen A;Malila NK;Pitkäniemi JM
通讯作者：
Pitkäniemi JM
影响因子：
--
作者：
Zheng, Xuanqi;Li, Xiao;Wu, Aimin
通讯作者：
Wu, Aimin
1992年至2008年，美国癌症幸存者第二次主要恶性肿瘤的风险。
影响因子：
6.2
作者：
Donin N;Filson C;Drakaki A;Tan HJ;Castillo A;Kwan L;Litwin M;Chamie K
通讯作者：
Chamie K
DOI：
10.1136/bmj.i851
发表时间：
2016-03-02
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Wallis CJ;Mahar AL;Choo R;Herschorn S;Kodama RT;Shah PS;Danjoux C;Narod SA;Nam RK
通讯作者：
Nam RK
影响因子：
10.3
作者：
Travis, LB;Fosså, SD;Gilbert, ES
通讯作者：
Gilbert, ES