Micronutrients: Essential Treatment for Inflammatory Arthritis?
Micronutrients: Essential Treatment for Inflammatory Arthritis?
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DOI：
10.1007/s11926-020-00962-z
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发表时间：
2020-10-26
影响因子：
5
通讯作者：
Guma M
中科院分区：
文献类型：
--
作者：
Bañuls-Mirete M;Ogdie A;Guma M
滑膜炎症是炎症性慢性关节病的特征，可导致进行性关节损害、慢性疼痛和功能丧失。科学研究越来越集中于研究水果、蔬菜、香料、种子、茶叶和葡萄酒中存在的抗炎微量营养素。本综述旨在研究多酚(植物中存在的植物营养素)和其他微量营养素在慢性炎症性关节病患者中进行的随机临床试验中的抗炎作用。越来越多的证据表明，微量营养素摄入的差异可能在滑膜炎的发病机制、治疗反应和缓解中发挥重要作用。通过摄取特定的微量营养素或营养丰富的食物进行的随机临床试验显示，症状得到改善，促炎和抗炎介质的调节都得到了改善。我们发现了令人信服的证据，证明了几种微量营养素在关节炎症状和炎症中的抗炎作用。尽管在临床实践中，对慢性关节炎症患者的营养建议并不是始终如一的，但在日常饮食习惯中添加这些营养物质可能会改变炎症性关节炎的自然历史。对于慢性滑膜炎症患者的具体营养建议，还需要进一步的研究才能达成共识。
Synovial inflammation is characteristic of inflammatory chronic arthropathies and can cause progressive articular damage, chronic pain, and functional loss. Scientific research has increasingly focused on investigating anti-inflammatory micronutrients present in fruits, vegetables, spices, seeds, tea, and wine. This review aims to examine the anti-inflammatory effect of polyphenols (phytonutrients present in plants) and other micronutrients described in randomized clinical trials conducted in patients with chronic inflammatory arthropathies. There is an increasing evidence that differences in micronutrient intake might play an essential role in pathogenesis, therapeutic response, and remission of synovitis. Randomized clinical trials with specific micronutrient- or nutrient-enriched food intake show improvement of symptoms and modulation of both pro- and anti-inflammatory mediators. We found convincing evidence of the anti-inflammatory effect of several micronutrients in arthritis symptoms and inflammation. Although in clinical practice nutritional recommendations to patients with chronic joint inflammation are not consistently prescribed, the addition of these nutrients to day-to-day eating habits could potentially change the natural history of inflammatory arthritis. Future research is needed for a consensus on the specific nutritional recommendations for patients with chronic synovial inflammation.
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