Diabetic flies? Using Drosophila melanogaster to understand the causes of monogenic and genetically complex diseases
Diabetic flies? Using Drosophila melanogaster to understand the causes of monogenic and genetically complex diseases
复制标题
糖尿病苍蝇？
作者：
P. Lasko
大约四分之三的人类疾病位点在果蝇黑腹果蝇中具有对应位点。因此，这种模式生物对于理解这些基因座在正常发育中的作用以及解开这些基因座参与的遗传途径是非常有价值的。果蝇在这些研究中的重要优势是其完整的基因组，已经存在的突变的无与伦比的集合，可以产生新突变的相对容易，存在易于观察和测量的用于灭活或过表达组织中基因的方便技术，以及容易进行第二位点修饰基因遗传学的能力。最近的工作在果蝇的胰岛素信号通路，具有深远的临床意义的途径，审查作为一个例证，这样的研究如何可以提供基本的见解，这条途径在调节生长和发育的功能。此外，果蝇的研究现在正在确定迄今为止未知的胰岛素信号调节剂，并指出该途径在抑制良性肿瘤形成和调节寿命方面的新功能。
Approximately three‐quarters of human disease loci have counterparts in the fruit fly Drosophila melanogaster. This model organism is therefore extremely valuable for using to understand the role of these loci in normal development, and for unravelling genetic pathways in which these loci take part. Important advantages for Drosophila in such studies are its completed genome, the unparalleled collection of mutations already in existence, the relative ease in which new mutations can be generated, the existence of convenient techniques for inactivating or overexpressing genes in dispensable tissues that are easily observed and measured, and the ability to readily carry out second‐site modifier genetics. Recent work in Drosophila on the insulin‐signaling pathway, a pathway of profound clinical importance, is reviewed as an illustration of how such research can provide fundamental insights into the functions of this pathway in regulating growth and development. Moreover, Drosophila research is now identifying heretofore unknown regulators of insulin signaling, as well as indicating novel functions for this pathway in suppressing benign tumor formation and regulating life span.
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影响因子：
3.3
作者：
Dennis R. LaJeunesse;Brooke M. McCartney;R. Fehon
通讯作者：
Dennis R. LaJeunesse;Brooke M. McCartney;R. Fehon
影响因子：
4.6
作者：
Angelica L. M. Cadavid;A. Ginzel;J. Fischer
通讯作者：
Angelica L. M. Cadavid;A. Ginzel;J. Fischer
影响因子：
10.5
作者：
Ghabrial, A;Ray, RP;Schüpbach, T
通讯作者：
Schüpbach, T
果蝇胚胎中 dpp 靶基因的调控。
DOI：
10.1242/dev.124.2.303
发表时间：
1997
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Rusch,J;Levine,M
通讯作者：
Levine,M
影响因子：
3.6
作者：
Peter Pörzgen;Sang Ki Park;J. Hirsh;M. Sonders;Susan G. Amara
通讯作者：
Peter Pörzgen;Sang Ki Park;J. Hirsh;M. Sonders;Susan G. Amara