Cardiac fibroblast in development and wound healing.
Cardiac fibroblast in development and wound healing.
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DOI：
10.1016/j.yjmcc.2014.02.017
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发表时间：
2014-05
影响因子：
5
通讯作者：
Ubil, Eric
中科院分区：
文献类型：
--
作者：
Deb, Arjun;Ubil, Eric
心脏成纤维细胞是哺乳动物心脏中最丰富的细胞类型，约占心脏细胞类型总数的三分之二。在发育过程中，心外膜细胞经历上皮-间质转化，生成心脏成纤维细胞，这些成纤维细胞随后迁移到发育中的心肌，成为常驻的心脏成纤维细胞。成纤维细胞在发育过程中为心肌细胞类型的附着形成结构支架，表达生长因子和细胞因子，调控胚胎心肌细胞的增殖。在出生后的生活中，心脏成纤维细胞在协调损伤反应中起着关键作用。心脏损伤后早期成纤维细胞的激活和增殖对维持心脏的完整性和功能至关重要，而成纤维细胞在损伤后长期存在会导致慢性瘢痕形成和不利的心室重构。在这篇综述中，我们讨论了成纤维细胞在心脏发育和伤口愈合过程中的生理功能，活化的分子介质可能是纤维化药物开发的可能靶点，最后使用重编程技术逆转疤痕。这篇文章是特刊“心肌中肌细胞-成纤维细胞信号传导”的一部分。
Cardiac fibroblasts are the most abundant cell type in the mammalian heart and comprise approximately two-thirds of the total number of cardiac cell types. During development, epicardial cells undergo epithelial–mesenchymal-transition to generate cardiac fibroblasts that subsequently migrate into the developing myocardium to become resident cardiac fibroblasts. Fibroblasts form a structural scaffold for the attachment of cardiac cell types during development, express growth factors and cytokines and regulate proliferation of embryonic cardiomyocytes. In post natal life, cardiac fibroblasts play a critical role in orchestrating an injury response. Fibroblast activation and proliferation early after cardiac injury are critical for maintaining cardiac integrity and function, while the persistence of fibroblasts long after injury leads to chronic scarring and adverse ventricular remodeling. In this review, we discuss the physiologic function of the fibroblast during cardiac development and wound healing, molecular mediators of activation that could be possible targets for drug development for fibrosis and finally the use of reprogramming technologies for reversing scar. This article is part of a Special Issue entitled "Myocyte-Fibroblast Signalling in Myocardium."
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DOI：
10.1152/ajpheart.00514.2007
发表时间：
2007-09-01
影响因子：
4.8
作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
39.3
作者：
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通讯作者：
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