Hox, Wnt, and the evolution of the primary body axis: insights from the early-divergent phyla.
Hox, Wnt, and the evolution of the primary body axis: insights from the early-divergent phyla.
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DOI：
10.1186/1745-6150-2-37
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发表时间：
2007-12-13
期刊：
影响因子：
5.5
通讯作者：
Baxevanis AD
中科院分区：
文献类型：
--
作者：
Ryan JF;Baxevanis AD
双体动物亚界包含了绝大多数动物，除了四个早期分支的门：孔动物门、栉水母门、扁平动物门和刺胞动物门。平均而言，这些早期分支的门有较少的细胞类型，组织和器官，并被认为是显着较少的专业化沿着他们的主要身体轴。因此，他们提出了一个有吸引力的外群，从中研究遗传工具包中的进化变化如何可能有助于出现复杂的动物身体计划的Bilateria。这篇评论提供了一个最新的一瞥bilaterians和这些早期分歧类群之间的基因组规模的比较。具体而言，我们研究这些数据的背景下，他们如何可能解释的进化发展的主要机构的轴和轴对称的后生动物。接下来，我们重新评估动物型假说的有效性和进化基因组相关性，该假说通过基因表达的特定空间模式来定义动物。最后，我们延伸的假设，Wnt基因可能是最早的主要身体轴图案化机制，建议Hox基因增选到这个图案化网络之前，刺胞动物和bilaterians的最后共同祖先。审核人：Pierre Pontarotti、Gáspár Jékely和L Aravind。对于完整的评论，请转到评论者的评论部分。
The subkingdom Bilateria encompasses the overwhelming majority of animals, including all but four early-branching phyla: Porifera, Ctenophora, Placozoa, and Cnidaria. On average, these early-branching phyla have fewer cell types, tissues, and organs, and are considered to be significantly less specialized along their primary body axis. As such, they present an attractive outgroup from which to investigate how evolutionary changes in the genetic toolkit may have contributed to the emergence of the complex animal body plans of the Bilateria. This review offers an up-to-date glimpse of genome-scale comparisons between bilaterians and these early-diverging taxa. Specifically, we examine these data in the context of how they may explain the evolutionary development of primary body axes and axial symmetry across the Metazoa. Next, we re-evaluate the validity and evolutionary genomic relevance of the zootype hypothesis, which defines an animal by a specific spatial pattern of gene expression. Finally, we extend the hypothesis that Wnt genes may be the earliest primary body axis patterning mechanism by suggesting that Hox genes were co-opted into this patterning network prior to the last common ancestor of cnidarians and bilaterians. Reviewed by Pierre Pontarotti, Gáspár Jékely, and L Aravind. For the full reviews, please go to the Reviewers' comments section.
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影响因子：
2.7
作者：
Augustin, Rene;Franke, Andre;Bosch, Thomas C. G.
通讯作者：
Bosch, Thomas C. G.
DOI：
10.1668/0003-1569(2001)041
发表时间：
2001-04-01
期刊：
AMERICAN ZOOLOGIST
影响因子：
--
作者：
Kramer, DL;McLaughlin, RL
通讯作者：
McLaughlin, RL
影响因子：
7
作者：
Bondos, SE;Tan, XX;Matthews, KS
通讯作者：
Matthews, KS
影响因子：
64.8
作者：
Brooke, NM;Garcia-Fernàndez, J;Holland, PWH
通讯作者：
Holland, PWH
影响因子：
3.9
作者：
Abouheif, E;Zardoya, R;Meyer, A
通讯作者：
Meyer, A