Switching cell fate: the remarkable rise of induced pluripotent stem cells and lineage reprogramming technologies.
Switching cell fate: the remarkable rise of induced pluripotent stem cells and lineage reprogramming technologies.
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转换细胞命运：诱导多能干细胞和谱系重编程技术的显着崛起。
DOI：
10.1016/j.tibtech.2010.01.002
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发表时间：
2010-04
影响因子：
17.3
通讯作者：
Deng, Wenbin
中科院分区：
文献类型：
--
作者：
Selvaraj, Vimal;Plane, Jennifer M.;Williams, Ambrose J.;Deng, Wenbin
细胞重编程（Cell reprogramming）是在生物技术和医学领域具有革命性前景的新兴领域，它使已分化的细胞改变其命运。最近通过体外重编程诱导多能性的发现为再生医学、理解人类疾病和药物发现开辟了前所未有的途径。此外，最近在体内通过直接谱系重编程进行再生和修复的研究为细胞治疗提供了一个有吸引力的新选择。尽管我们在细胞重编程领域不断突破现有知识的极限，但这些过程背后的机制因素在很大程度上仍然难以捉摸。本文回顾了细胞重编程的里程碑式发展，当前的知识和技术发展，现在在生物医学应用方面具有重要的前景。
Cell reprogramming, in which a differentiated cell is made to switch its fate, is an emerging field with revolutionary prospects in biotechnology and medicine. The recent discovery of induced pluripotency by means of in vitro reprogramming has made way for unprecedented approaches for regenerative medicine, understanding human disease and drug discovery. Moreover, recent studies on regeneration and repair by direct lineage reprogramming in vivo offer an attractive novel alternative to cell therapy. Although we continue to push the limits of current knowledge in the field of cell reprogramming, the mechanistic elements underlying these processes remain largely elusive. This article reviews landmark developments in cell reprogramming, the current knowledge and technological developments now on the horizon with significant promise for biomedical applications.
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影响因子：
64.8
作者：
Gaspar-Maia A;Alajem A;Polesso F;Sridharan R;Mason MJ;Heidersbach A;Ramalho-Santos J;McManus MT;Plath K;Meshorer E;Ramalho-Santos M
通讯作者：
Ramalho-Santos M
影响因子：
64.8
作者：
Eggan, E;Baldwin, K;Jaenisch, R
通讯作者：
Jaenisch, R
影响因子：
23.9
作者：
Ichida JK;Blanchard J;Lam K;Son EY;Chung JE;Egli D;Loh KM;Carter AC;Di Giorgio FP;Koszka K;Huangfu D;Akutsu H;Liu DR;Rubin LL;Eggan K
通讯作者：
Eggan K
影响因子：
10.5
作者：
Banito, Ana;Rashid, Sheikh T.;Gil, Jesus
通讯作者：
Gil, Jesus
影响因子：
7.7
作者：
BONNERWEIR, S;BAXTER, LA;SMITH, FE
通讯作者：
SMITH, FE