The hypertrophic amygdala shape associated with anxiety in patients with primary dysmenorrhea during pain-free phase: insight from surface-based shape analysis.
The hypertrophic amygdala shape associated with anxiety in patients with primary dysmenorrhea during pain-free phase: insight from surface-based shape analysis.
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DOI：
10.1007/s11682-022-00664-3
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发表时间：
2022-10
影响因子：
3.2
通讯作者：
Yang, Jie
中科院分区：
文献类型：
--
作者：
Yu, Siyi;Wei, Wei;Liu, Liying;Guo, Xiaoli;Shen, Zhifu;Tian, Jin;Zeng, Fang;Liang, Fanrong;Yang, Jie
原发性痛经（PDM）与情绪症状高度相关。然而，这些合并症的神经病理学尚不清楚。在本研究中，我们的目的是调查的结构变化，在杏仁核的PDM患者在无痛期使用基于表面的形状分析。研究招募了43名PDM患者和40名健康对照，所有参与者在排卵期接受了结构磁共振成像扫描。采用FMRIB的集成配准和分割工具（FIRST）评估PDM患者的皮质下体积和表面改变。并采用相关分析和中介分析探讨皮质下形态计量学改变的临床意义。PDM患者左侧杏仁核浅层、右侧基底外侧核及浅层均出现肥大改变，但杏仁核整体体积未见明显改变。杏仁核肥大与病程、疼痛严重程度和月经期焦虑症状有关。此外，肥大的左杏仁核可以介导疾病持续时间和焦虑严重程度之间的关联。目前的研究结果表明，局限性杏仁核形状肥大存在于PDM患者，即使在无痛阶段。此外，肥大杏仁核的中介作用表明杏仁核在PDM治疗的无痛阶段的焦虑治疗的潜在目标。在线版本包含补充材料，可通过10.1007/s11682-022-00664-3获取。
Primary dysmenorrhea (PDM) is highly associated with mood symptoms. However, the neuropathology of these comorbidities is unclear. In the present study, we aimed to investigate the structural changes in the amygdala of patients with PDM during the pain-free phase using a surface-based shape analysis. Forty-three PDM patients and forty healthy controls were recruited in the study, and all participants underwent structural magnetic resonance imaging scans during their periovulatory phase. FMRIB’s Integrated Registration and Segmentation Tool (FIRST) was employed to assess the subcortical volumetric and surface alterations in patients with PDM. Moreover, correlation and mediation analyses were used to detect the clinical significance of the subcortical morphometry alteration. PDM patients showed hypertrophic alteration of the amygdala in the left superficial nuclei and right basolateral and superficial nuclei but not for the whole amygdala volume. The hypertrophic amygdala was associated with disease duration, pain severity and anxiety symptoms during the menstrual period. Furthermore, the hypertrophic left amygdala could mediate the association between disease duration and anxiety severity. The results of the current study demonstrated that the localized amygdala shape hypertrophy was present in PDM patients even in the pain-free phase. In addition, the mediator role of the hypertrophic amygdala indicates the potential target of amygdala for anxiety treatment in PDM treatment in the pain-free phase. The online version contains supplementary material available at 10.1007/s11682-022-00664-3.
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影响因子：
4.8
作者：
Gutman BA;van Erp TGM;Alpert K;Ching CRK;Isaev D;Ragothaman A;Jahanshad N;Saremi A;Zavaliangos-Petropulu A;Glahn DC;Shen L;Cong S;Alnaes D;Andreassen OA;Doan NT;Westlye LT;Kochunov P;Satterthwaite TD;Wolf DH;Huang AJ;Kessler C;Weideman A;Nguyen D;Mueller BA;Faziola L;Potkin SG;Preda A;Mathalon DH;Bustillo J;Calhoun V;Ford JM;Walton E;Ehrlich S;Ducci G;Banaj N;Piras F;Piras F;Spalletta G;Canales-Rodríguez EJ;Fuentes-Claramonte P;Pomarol-Clotet E;Radua J;Salvador R;Sarró S;Dickie EW;Voineskos A;Tordesillas-Gutiérrez D;Crespo-Facorro B;Setién-Suero E;van Son JM;Borgwardt S;Schönborn-Harrisberger F;Morris D;Donohoe G;Holleran L;Cannon D;McDonald C;Corvin A;Gill M;Filho GB;Rosa PGP;Serpa MH;Zanetti MV;Lebedeva I;Kaleda V;Tomyshev A;Crow T;James A;Cervenka S;Sellgren CM;Fatouros-Bergman H;Agartz I;Howells F;Stein DJ;Temmingh H;Uhlmann A;de Zubicaray GI;McMahon KL;Wright M;Cobia D;Csernansky JG;Thompson PM;Turner JA;Wang L
通讯作者：
Wang L
影响因子：
5.7
作者：
Patenaude, Brian;Smith, Stephen M.;Kennedy, David N.;Jenkinson, Mark
通讯作者：
Jenkinson, Mark
影响因子：
4.8
作者：
Morey, Rajendra A.;Selgrade, Elizabeth S.;Wagner, Henry Ryan, II;Huettel, Scott A.;Wang, Lihong;McCarthy, Gregory
通讯作者：
McCarthy, Gregory
影响因子：
5.7
作者：
Morey RA;Petty CM;Xu Y;Hayes JP;Wagner HR 2nd;Lewis DV;LaBar KS;Styner M;McCarthy G
通讯作者：
McCarthy G
影响因子：
2.6
作者：
Pessoa L
通讯作者：
Pessoa L