A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium.
A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium.
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DOI：
10.1002/hbm.25625
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发表时间：
2022-01
影响因子：
4.8
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Gutman BA;van Erp TGM;Alpert K;Ching CRK;Isaev D;Ragothaman A;Jahanshad N;Saremi A;Zavaliangos-Petropulu A;Glahn DC;Shen L;Cong S;Alnaes D;Andreassen OA;Doan NT;Westlye LT;Kochunov P;Satterthwaite TD;Wolf DH;Huang AJ;Kessler C;Weideman A;Nguyen D;Mueller BA;Faziola L;Potkin SG;Preda A;Mathalon DH;Bustillo J;Calhoun V;Ford JM;Walton E;Ehrlich S;Ducci G;Banaj N;Piras F;Piras F;Spalletta G;Canales-Rodríguez EJ;Fuentes-Claramonte P;Pomarol-Clotet E;Radua J;Salvador R;Sarró S;Dickie EW;Voineskos A;Tordesillas-Gutiérrez D;Crespo-Facorro B;Setién-Suero E;van Son JM;Borgwardt S;Schönborn-Harrisberger F;Morris D;Donohoe G;Holleran L;Cannon D;McDonald C;Corvin A;Gill M;Filho GB;Rosa PGP;Serpa MH;Zanetti MV;Lebedeva I;Kaleda V;Tomyshev A;Crow T;James A;Cervenka S;Sellgren CM;Fatouros-Bergman H;Agartz I;Howells F;Stein DJ;Temmingh H;Uhlmann A;de Zubicaray GI;McMahon KL;Wright M;Cobia D;Csernansky JG;Thompson PM;Turner JA;Wang L
精神分裂症与大脑皮层下结构的广泛改变有关。虽然分析方法使更详细的形态计量特征，结果往往是模棱两可的。在这项meta分析中，我们采用统一的ENIGMA形状分析方案，共同研究精神分裂症患者和健康对照者皮质下脑结构形状的差异。该研究分析了参加ENIGMA精神分裂症工作组的21个全球研究小组提供的2,833名精神分裂症患者和3,929名健康对照参与者的数据。统一的形状分析方案应用于从T1加权结构MRI扫描中获得的双侧海马、杏仁核、尾状核、伏隔核、壳核、苍白球和丘脑的每个部位的独立数据。大量单变量meta分析显示，与对照组相比，精神分裂症患者海马、杏仁核、伏隔核和丘脑的凹型比凸型差异更大，壳核和白质的凸型比凹型差异更大，尾状核的凹型和凸型都存在差异。与对照组相比，在精神分裂症患者的海马体、杏仁核和丘脑中观察到夸张的不对称模式，而在腹侧纹状体、腹侧和背侧丘脑中观察到不对称模式的减少。我们的分析还显示，较高的氯丙嗪当量剂量和增加的阳性症状水平与多个皮质下结构的连续凸形状差异模式有关。我们的形状元分析结果表明，共同的神经生物学机制可能有助于多个皮层下区域的灰质减少，从而增强了我们对精神分裂症网络紊乱本质的理解。我们的论文报道了迄今为止第一项大型前瞻性皮质下形状meta分析，比较了精神分裂症患者和健康对照者。全球21个机构通过精神分裂症工作组增强神经成像遗传学Meta分析（ENIGMA）联盟提供了24个横断面研究样本，共2833名精神分裂症患者和3929名健康对照者。该研究采用前瞻性元分析方法，采用最先进的协调形状分析方案。我们报告了皮层下形状和不对称差异的强大模式，以及跨越多个相邻皮层下结构的药物和症状的关联，这在以前的个体研究中没有一致性的报道。
Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta‐analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1‐weighted structural MRI scans. Mass univariate meta‐analyses revealed more‐concave‐than‐convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more‐convex‐than‐concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta‐analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia. Our manuscript reports the first, large prospective subcortical shape meta‐analysis to date, comparing individuals with schizophrenia and healthy controls. Twenty‐one institutions worldwide contributed 24 cross‐sectional study samples to this study via the Enhancing Neuro Imaging Genetics Through Meta‐Analysis (ENIGMA) Consortium, Schizophrenia Working Group, totaling 2,833 individuals with schizophrenia and 3,929 healthy controls. The study utilized a prospective meta‐analysis approach with state‐of‐the‐art harmonized shape analysis protocols. We report robust patterns of subcortical shape and asymmetry differences, and associations with medication and symptoms that spanned multiple neighboring subcortical structures, which have not been previously reported in individual studies with consistency.
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